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ARG2 ARG2 ARG1 ARG1 AGMAT AGMAT HAL HAL AMDHD1 AMDHD1 GBP7 GBP7 FTCD FTCD UROC1 UROC1 GDA GDA LECT2 LECT2 ADH4 ADH4
"UROC1" - Urocanate hydratase 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UROC1Urocanate hydratase 1 (736 aa)    
Predicted Functional Partners:
HAL
Histidine ammonia-lyase (657 aa)
score_image   score_image score_image   score_image score_image   0.992
AMDHD1
Amidohydrolase domain containing 1 (426 aa)
score_image   score_image score_image   score_image score_image   0.989
FTCD
Formiminotransferase cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (541 aa)
score_image   score_image score_image     score_image   0.869
ADH4
Alcohol dehydrogenase 4 (class II), pi polypeptide (380 aa)
      score_image         0.487
AGMAT
Agmatine ureohydrolase (agmatinase) (352 aa)
score_image     score_image     score_image   0.477
LECT2
Leukocyte cell-derived chemotaxin 2; Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (151 aa)
      score_image         0.475
ARG1
Arginase, liver (322 aa)
score_image     score_image     score_image   0.471
ARG2
Arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders (354 aa)
score_image     score_image     score_image   0.471
GBP7
Guanylate binding protein 7; Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity) (638 aa)
      score_image         0.459
GDA
Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (471 aa)
score_image         score_image score_image   0.443
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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