| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AHSG | ALB | ENSBTAP00000000673 | ENSBTAP00000022763 | Alpha-2-HS-glycoprotein ; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone | Serum albumin ; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc | 0.975 |
| AHSG | APOA1 | ENSBTAP00000000673 | ENSBTAP00000002914 | Alpha-2-HS-glycoprotein ; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone | Apolipoprotein A-I Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | 0.578 |
| AHSG | ENSBTAG00000005339 | ENSBTAP00000000673 | ENSBTAP00000007026 | Alpha-2-HS-glycoprotein ; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone | Vascular endothelial growth factor A | 0.903 |
| AHSG | HPX | ENSBTAP00000000673 | ENSBTAP00000004635 | Alpha-2-HS-glycoprotein ; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone | Hemopexin ; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation | 0.404 |
| AHSG | IGF1 | ENSBTAP00000000673 | ENSBTAP00000055243 | Alpha-2-HS-glycoprotein ; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone | Insulin-like growth factor I ; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (By similarity). Ca(2 [...] | 0.909 |
| AHSG | IGF2 | ENSBTAP00000000673 | ENSBTAP00000017372 | Alpha-2-HS-glycoprotein ; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone | Insulin-like growth factor II Insulin-like growth factor II Preptin; The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development | 0.905 |
| AHSG | SERPINA1 | ENSBTAP00000000673 | ENSBTAP00000004927 | Alpha-2-HS-glycoprotein ; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone | Alpha-1-antiproteinase ; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Inhibits trypsin, chymotrypsin and plasminogen activator (By similarity) | 0.938 |
| AHSG | SERPINE1 | ENSBTAP00000000673 | ENSBTAP00000019232 | Alpha-2-HS-glycoprotein ; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone | Plasminogen activator inhibitor 1 ; Serine protease inhibitor. This inhibitor acts as ’bait’ for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis (By similarity) | 0.908 |
| AHSG | SERPINF2 | ENSBTAP00000000673 | ENSBTAP00000027793 | Alpha-2-HS-glycoprotein ; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone | Alpha-2-antiplasmin ; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin (By similarity) | 0.915 |
| AHSG | TIMP1 | ENSBTAP00000000673 | ENSBTAP00000006653 | Alpha-2-HS-glycoprotein ; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone | Metalloproteinase inhibitor 1 ; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling | 0.901 |
| ALB | AHSG | ENSBTAP00000022763 | ENSBTAP00000000673 | Serum albumin ; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc | Alpha-2-HS-glycoprotein ; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone | 0.975 |
| ALB | APOA1 | ENSBTAP00000022763 | ENSBTAP00000002914 | Serum albumin ; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc | Apolipoprotein A-I Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility | 0.968 |
| ALB | ENSBTAG00000005339 | ENSBTAP00000022763 | ENSBTAP00000007026 | Serum albumin ; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc | Vascular endothelial growth factor A | 0.979 |
| ALB | HPX | ENSBTAP00000022763 | ENSBTAP00000004635 | Serum albumin ; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc | Hemopexin ; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation | 0.966 |
| ALB | IGF1 | ENSBTAP00000022763 | ENSBTAP00000055243 | Serum albumin ; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc | Insulin-like growth factor I ; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (By similarity). Ca(2 [...] | 0.978 |
| ALB | IGF2 | ENSBTAP00000022763 | ENSBTAP00000017372 | Serum albumin ; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc | Insulin-like growth factor II Insulin-like growth factor II Preptin; The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development | 0.953 |
| ALB | SERPINA1 | ENSBTAP00000022763 | ENSBTAP00000004927 | Serum albumin ; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc | Alpha-1-antiproteinase ; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Inhibits trypsin, chymotrypsin and plasminogen activator (By similarity) | 0.952 |
| ALB | SERPINE1 | ENSBTAP00000022763 | ENSBTAP00000019232 | Serum albumin ; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc | Plasminogen activator inhibitor 1 ; Serine protease inhibitor. This inhibitor acts as ’bait’ for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis (By similarity) | 0.971 |
| ALB | SERPINF2 | ENSBTAP00000022763 | ENSBTAP00000027793 | Serum albumin ; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc | Alpha-2-antiplasmin ; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin (By similarity) | 0.961 |
| ALB | TIMP1 | ENSBTAP00000022763 | ENSBTAP00000006653 | Serum albumin ; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc | Metalloproteinase inhibitor 1 ; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling | 0.953 |
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