AKAP17A protein (Homo sapiens) - STRING network view

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AKAP17A

A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner (695 aa)

Predicted Functional Partners:

ASMTL

0.691

ZRANB2

0.663

BCR

0.605

ARHGAP6

0.576

UNC50

0.575

ASMT

0.524

TGIF2LX

0.522

CDYL2

0.515

CD22

0.491

NIPA2

0.463

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP17A	ARHGAP6	ENSP00000324827	ENSP00000338967	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	Rho GTPase activating protein 6; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology	0.576
AKAP17A	ASMT	ENSP00000324827	ENSP00000370639	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	Acetylserotonin O-methyltransferase	0.524
AKAP17A	ASMTL	ENSP00000324827	ENSP00000370718	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	Acetylserotonin O-methyltransferase-like; Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity	0.691
AKAP17A	BCR	ENSP00000324827	ENSP00000303507	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	Breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity	0.605
AKAP17A	CD22	ENSP00000324827	ENSP00000085219	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	CD22 molecule; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an [...]	0.491
AKAP17A	CDYL2	ENSP00000324827	ENSP00000299564	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	Chromodomain protein, Y-like 2	0.515
AKAP17A	NIPA2	ENSP00000324827	ENSP00000337618	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	Non imprinted in Prader-Willi/Angelman syndrome 2; Acts as a selective Mg(2+) transporter	0.463
AKAP17A	TGIF2LX	ENSP00000324827	ENSP00000355119	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	TGFB-induced factor homeobox 2-like, X-linked; May have a transcription role in testis	0.522
AKAP17A	UNC50	ENSP00000324827	ENSP00000350409	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	Unc-50 homolog (C. elegans); May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity)	0.575
AKAP17A	ZRANB2	ENSP00000324827	ENSP00000359958	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	Zinc finger, RAN-binding domain containing 2; Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5’- splice site selection	0.663
ARHGAP6	AKAP17A	ENSP00000338967	ENSP00000324827	Rho GTPase activating protein 6; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	0.576
ARHGAP6	NIPA2	ENSP00000338967	ENSP00000337618	Rho GTPase activating protein 6; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology	Non imprinted in Prader-Willi/Angelman syndrome 2; Acts as a selective Mg(2+) transporter	0.469
ARHGAP6	UNC50	ENSP00000338967	ENSP00000350409	Rho GTPase activating protein 6; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology	Unc-50 homolog (C. elegans); May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity)	0.575
ASMT	AKAP17A	ENSP00000370639	ENSP00000324827	Acetylserotonin O-methyltransferase	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	0.524
ASMTL	AKAP17A	ENSP00000370718	ENSP00000324827	Acetylserotonin O-methyltransferase-like; Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	0.691
BCR	AKAP17A	ENSP00000303507	ENSP00000324827	Breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	0.605
BCR	CD22	ENSP00000303507	ENSP00000085219	Breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity	CD22 molecule; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an [...]	0.774
CD22	AKAP17A	ENSP00000085219	ENSP00000324827	CD22 molecule; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an [...]	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	0.491
CD22	BCR	ENSP00000085219	ENSP00000303507	CD22 molecule; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an [...]	Breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity	0.774
CDYL2	AKAP17A	ENSP00000299564	ENSP00000324827	Chromodomain protein, Y-like 2	A kinase (PRKA) anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner	0.515

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