| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADORA1 | CCR2 | ENSP00000308549 | ENSP00000292301 | Adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | Chemokine (C-C motif) receptor 2; Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection | 0.902 |
| ADORA1 | CXCR2 | ENSP00000308549 | ENSP00000319635 | Adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | Chemokine (C-X-C motif) receptor 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 | 0.902 |
| ADORA1 | FPR1 | ENSP00000308549 | ENSP00000302707 | Adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | Formyl peptide receptor 1; High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed-2161213, PubMed-2176894, PubMed-10514456, PubMed-15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed-2161213, PubMed-1712023, PubMed-15153520). This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed-1712023, PubMed-10514456) | 0.901 |
| ADORA1 | FPR2 | ENSP00000308549 | ENSP00000340191 | Adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | Formyl peptide receptor 2; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) | 0.900 |
| ADORA1 | IL8 | ENSP00000308549 | ENSP00000306512 | Adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | Interleukin 8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively | 0.914 |
| ADORA1 | KNG1 | ENSP00000308549 | ENSP00000265023 | Adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | Kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.948 |
| ADORA1 | OXGR1 | ENSP00000308549 | ENSP00000298440 | Adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | Oxoglutarate (alpha-ketoglutarate) receptor 1; Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity) | 0.906 |
| ADORA1 | P2RY13 | ENSP00000308549 | ENSP00000320376 | Adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | Purinergic receptor P2Y, G-protein coupled, 13; Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system | 0.921 |
| ADORA1 | P2RY14 | ENSP00000308549 | ENSP00000308361 | Adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | Purinergic receptor P2Y, G-protein coupled, 14; Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP | 0.917 |
| ADORA1 | P2RY4 | ENSP00000308549 | ENSP00000363643 | Adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | Pyrimidinergic receptor P2Y, G-protein coupled, 4; Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP | 0.929 |
| CCR2 | ADORA1 | ENSP00000292301 | ENSP00000308549 | Chemokine (C-C motif) receptor 2; Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection | Adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | 0.902 |
| CCR2 | CXCR2 | ENSP00000292301 | ENSP00000319635 | Chemokine (C-C motif) receptor 2; Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection | Chemokine (C-X-C motif) receptor 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 | 0.921 |
| CCR2 | FPR1 | ENSP00000292301 | ENSP00000302707 | Chemokine (C-C motif) receptor 2; Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection | Formyl peptide receptor 1; High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed-2161213, PubMed-2176894, PubMed-10514456, PubMed-15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed-2161213, PubMed-1712023, PubMed-15153520). This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed-1712023, PubMed-10514456) | 0.905 |
| CCR2 | FPR2 | ENSP00000292301 | ENSP00000340191 | Chemokine (C-C motif) receptor 2; Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection | Formyl peptide receptor 2; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) | 0.917 |
| CCR2 | IL8 | ENSP00000292301 | ENSP00000306512 | Chemokine (C-C motif) receptor 2; Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection | Interleukin 8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively | 0.970 |
| CCR2 | KNG1 | ENSP00000292301 | ENSP00000265023 | Chemokine (C-C motif) receptor 2; Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection | Kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.920 |
| CCR2 | OXGR1 | ENSP00000292301 | ENSP00000298440 | Chemokine (C-C motif) receptor 2; Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection | Oxoglutarate (alpha-ketoglutarate) receptor 1; Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity) | 0.900 |
| CCR2 | P2RY13 | ENSP00000292301 | ENSP00000320376 | Chemokine (C-C motif) receptor 2; Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection | Purinergic receptor P2Y, G-protein coupled, 13; Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system | 0.915 |
| CCR2 | P2RY14 | ENSP00000292301 | ENSP00000308361 | Chemokine (C-C motif) receptor 2; Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection | Purinergic receptor P2Y, G-protein coupled, 14; Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP | 0.903 |
| CCR2 | P2RY4 | ENSP00000292301 | ENSP00000363643 | Chemokine (C-C motif) receptor 2; Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection | Pyrimidinergic receptor P2Y, G-protein coupled, 4; Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP | 0.901 |
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