(8 nodes) Transmembrane channel-like protein network (Homo sapiens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TMC4	Transmembrane channel-like protein 4; Probable ion channel. (712 aa)
	TMC8	Transmembrane channel-like protein 8; Probable ion channel; Belongs to the TMC family. (726 aa)
	TMC2	Transmembrane channel-like protein 2; Probable ion channel required for the normal function of cochlear hair cells. Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity). (906 aa)
	TMC3	Transmembrane channel-like protein 3; Probable ion channel. (1100 aa)
	TMC5	Transmembrane channel-like protein 5; Probable ion channel. (1006 aa)
	TMC7	Transmembrane channel-like protein 7; Probable ion channel. (758 aa)
	TMC6	Transmembrane channel-like protein 6; Probable ion channel; Belongs to the TMC family. (805 aa)
	TMC1	Transmembrane channel-like protein 1; Probable ion channel required for the normal function of cochlear hair cells; Belongs to the TMC family. (760 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TMC1	TMC2	ENSP00000494684	ENSP00000351732	Transmembrane channel-like protein 1; Probable ion channel required for the normal function of cochlear hair cells; Belongs to the TMC family.	Transmembrane channel-like protein 2; Probable ion channel required for the normal function of cochlear hair cells. Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity).	0.893
TMC2	TMC1	ENSP00000351732	ENSP00000494684	Transmembrane channel-like protein 2; Probable ion channel required for the normal function of cochlear hair cells. Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity).	Transmembrane channel-like protein 1; Probable ion channel required for the normal function of cochlear hair cells; Belongs to the TMC family.	0.893
TMC6	TMC8	ENSP00000465261	ENSP00000325561	Transmembrane channel-like protein 6; Probable ion channel; Belongs to the TMC family.	Transmembrane channel-like protein 8; Probable ion channel; Belongs to the TMC family.	0.740
TMC8	TMC6	ENSP00000325561	ENSP00000465261	Transmembrane channel-like protein 8; Probable ion channel; Belongs to the TMC family.	Transmembrane channel-like protein 6; Probable ion channel; Belongs to the TMC family.	0.740