node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cdaR | degP | b0162 | b0161 | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | Serine endoprotease (protease Do), membrane-associated; DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. Degrades transiently denatured and unfolded or misfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. [...] | 0.478 |
cdaR | fucR | b0162 | b2805 | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | L-fucose operon activator; Transcriptional activator of the fuc operon. | 0.503 |
cdaR | garK | b0162 | b3124 | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | Glycerate kinase I; Protein involved in carbohydrate catabolic process; Belongs to the glycerate kinase type-1 family. | 0.640 |
cdaR | glxK | b0162 | b0514 | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | Glycerate kinase II; Protein involved in carbohydrate catabolic process, glycolate metabolic process and allantoin assimilation pathway; Belongs to the glycerate kinase type-1 family. | 0.510 |
cdaR | mukB | b0162 | b0924 | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | Chromosome condensin MukBEF, ATPase and DNA-binding subunit; Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV. | 0.417 |
cdaR | narQ | b0162 | b2469 | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | Sensory histidine kinase in two-component regulatory system with NarP; Acts as a sensor for nitrate/nitrite and transduces signal of nitrate/nitrite availability to the NarL/NarP proteins. NarQ probably activates NarL and NarP by phosphorylation. NarQ probably negatively regulates the NarL protein by dephosphorylation. | 0.419 |
cdaR | pgpB | b0162 | b1278 | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | Phosphatidylglycerophosphatase B; Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location, PGP phosphatase activity is higher in the cytoplasmic membrane, whereas PA and LPA phosphatase activities are [...] | 0.598 |
cdaR | sfsA | b0162 | b0146 | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | Sugar fermentation stimulation protein A; Binds to DNA non-specifically. Could be a regulatory factor involved in maltose metabolism. | 0.435 |
cdaR | uhpB | b0162 | b3668 | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | Sensory histidine kinase in two-component regulatory sytem with UhpA; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpB functions as a membrane-associated protein kinase that autophosphorylates in response to interaction with UhpC, and subsequently transfers its phosphate group to the response regulator UhpA. Can also dephosphorylate UhpA. | 0.426 |
cdaR | yhbP | b0162 | b3154 | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | UPF0306 family protein; Belongs to the UPF0306 family. | 0.421 |
degP | cdaR | b0161 | b0162 | Serine endoprotease (protease Do), membrane-associated; DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. Degrades transiently denatured and unfolded or misfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. [...] | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | 0.478 |
fucR | cdaR | b2805 | b0162 | L-fucose operon activator; Transcriptional activator of the fuc operon. | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | 0.503 |
garK | cdaR | b3124 | b0162 | Glycerate kinase I; Protein involved in carbohydrate catabolic process; Belongs to the glycerate kinase type-1 family. | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | 0.640 |
garK | glxK | b3124 | b0514 | Glycerate kinase I; Protein involved in carbohydrate catabolic process; Belongs to the glycerate kinase type-1 family. | Glycerate kinase II; Protein involved in carbohydrate catabolic process, glycolate metabolic process and allantoin assimilation pathway; Belongs to the glycerate kinase type-1 family. | 0.908 |
glxK | cdaR | b0514 | b0162 | Glycerate kinase II; Protein involved in carbohydrate catabolic process, glycolate metabolic process and allantoin assimilation pathway; Belongs to the glycerate kinase type-1 family. | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | 0.510 |
glxK | garK | b0514 | b3124 | Glycerate kinase II; Protein involved in carbohydrate catabolic process, glycolate metabolic process and allantoin assimilation pathway; Belongs to the glycerate kinase type-1 family. | Glycerate kinase I; Protein involved in carbohydrate catabolic process; Belongs to the glycerate kinase type-1 family. | 0.908 |
mukB | cdaR | b0924 | b0162 | Chromosome condensin MukBEF, ATPase and DNA-binding subunit; Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV. | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | 0.417 |
mukB | pgpB | b0924 | b1278 | Chromosome condensin MukBEF, ATPase and DNA-binding subunit; Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV. | Phosphatidylglycerophosphatase B; Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location, PGP phosphatase activity is higher in the cytoplasmic membrane, whereas PA and LPA phosphatase activities are [...] | 0.758 |
mukB | yhbP | b0924 | b3154 | Chromosome condensin MukBEF, ATPase and DNA-binding subunit; Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV. | UPF0306 family protein; Belongs to the UPF0306 family. | 0.664 |
narQ | cdaR | b2469 | b0162 | Sensory histidine kinase in two-component regulatory system with NarP; Acts as a sensor for nitrate/nitrite and transduces signal of nitrate/nitrite availability to the NarL/NarP proteins. NarQ probably activates NarL and NarP by phosphorylation. NarQ probably negatively regulates the NarL protein by dephosphorylation. | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. | 0.419 |