node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
gloB | mltD | b0212 | b0211 | Hydroxyacylglutathione hydrolase; Type II glyoxalase that catalyzes the hydrolysis of (R)-S- lactoylglutathione to (R)-lactate and glutathione. Is more efficient than the isozyme GloC, and plays a major contribution to methylglyoxal (MG) detoxification in E.coli. The two isoenzymes have additive effects and ensure maximal MG degradation. | Putative membrane-bound lytic murein transglycosylase D; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity); Belongs to the transglycosylase Slt family. | 0.662 |
gloB | yafS | b0212 | b0213 | Hydroxyacylglutathione hydrolase; Type II glyoxalase that catalyzes the hydrolysis of (R)-S- lactoylglutathione to (R)-lactate and glutathione. Is more efficient than the isozyme GloC, and plays a major contribution to methylglyoxal (MG) detoxification in E.coli. The two isoenzymes have additive effects and ensure maximal MG degradation. | Putative S-adenosyl-L-methionine-dependent methyltransferase. | 0.851 |
mltD | gloB | b0211 | b0212 | Putative membrane-bound lytic murein transglycosylase D; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity); Belongs to the transglycosylase Slt family. | Hydroxyacylglutathione hydrolase; Type II glyoxalase that catalyzes the hydrolysis of (R)-S- lactoylglutathione to (R)-lactate and glutathione. Is more efficient than the isozyme GloC, and plays a major contribution to methylglyoxal (MG) detoxification in E.coli. The two isoenzymes have additive effects and ensure maximal MG degradation. | 0.662 |
mltD | yafS | b0211 | b0213 | Putative membrane-bound lytic murein transglycosylase D; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity); Belongs to the transglycosylase Slt family. | Putative S-adenosyl-L-methionine-dependent methyltransferase. | 0.709 |
rseB | yafS | b2571 | b0213 | Anti-sigma E factor, binds RseA; Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS, which is probably relieved by lipopolysaccharide binding (LPS). Belongs to the RseB family. | Putative S-adenosyl-L-methionine-dependent methyltransferase. | 0.751 |
rseB | yejL | b2571 | b2187 | Anti-sigma E factor, binds RseA; Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS, which is probably relieved by lipopolysaccharide binding (LPS). Belongs to the RseB family. | UPF0352 family protein; Belongs to the UPF0352 family. | 0.679 |
rseB | yqiC | b2571 | b3042 | Anti-sigma E factor, binds RseA; Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS, which is probably relieved by lipopolysaccharide binding (LPS). Belongs to the RseB family. | BMFP family putative fusogenic protein; Required for efficient ubiquinone (coenzyme Q) biosynthesis under aerobic conditions. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both. Dispensable for ubiquinone biosynthesis under anaerobiosis. | 0.556 |
smtA | yafE | b0921 | b0210 | Putative S-adenosyl-L-methionine-dependent methyltransferase; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs. Four tRNAs (tRNA(Ala1), tRNA(Ser1), tRNA(Pro3) and tRNA(Thr4)) are fully modified with mcmo5U in stationary-phase E.coli. Also present at low frequency in tRNA(Leu3) and tRNA(Val1). | Putative S-adenosyl-L-methionine-dependent methyltransferase; Putative biotin synthesis protein; Protein involved in biotin biosynthetic process; Belongs to the methyltransferase superfamily. | 0.808 |
smtA | yafS | b0921 | b0213 | Putative S-adenosyl-L-methionine-dependent methyltransferase; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs. Four tRNAs (tRNA(Ala1), tRNA(Ser1), tRNA(Pro3) and tRNA(Thr4)) are fully modified with mcmo5U in stationary-phase E.coli. Also present at low frequency in tRNA(Leu3) and tRNA(Val1). | Putative S-adenosyl-L-methionine-dependent methyltransferase. | 0.668 |
smtA | yjhP | b0921 | b4306 | Putative S-adenosyl-L-methionine-dependent methyltransferase; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs. Four tRNAs (tRNA(Ala1), tRNA(Ser1), tRNA(Pro3) and tRNA(Thr4)) are fully modified with mcmo5U in stationary-phase E.coli. Also present at low frequency in tRNA(Leu3) and tRNA(Val1). | Uncharacterized protein YjhP; Pseudogene, zinc finger protein family. | 0.421 |
yafE | smtA | b0210 | b0921 | Putative S-adenosyl-L-methionine-dependent methyltransferase; Putative biotin synthesis protein; Protein involved in biotin biosynthetic process; Belongs to the methyltransferase superfamily. | Putative S-adenosyl-L-methionine-dependent methyltransferase; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs. Four tRNAs (tRNA(Ala1), tRNA(Ser1), tRNA(Pro3) and tRNA(Thr4)) are fully modified with mcmo5U in stationary-phase E.coli. Also present at low frequency in tRNA(Leu3) and tRNA(Val1). | 0.808 |
yafE | yafS | b0210 | b0213 | Putative S-adenosyl-L-methionine-dependent methyltransferase; Putative biotin synthesis protein; Protein involved in biotin biosynthetic process; Belongs to the methyltransferase superfamily. | Putative S-adenosyl-L-methionine-dependent methyltransferase. | 0.905 |
yafE | yjhP | b0210 | b4306 | Putative S-adenosyl-L-methionine-dependent methyltransferase; Putative biotin synthesis protein; Protein involved in biotin biosynthetic process; Belongs to the methyltransferase superfamily. | Uncharacterized protein YjhP; Pseudogene, zinc finger protein family. | 0.900 |
yafE | yjtD | b0210 | b4403 | Putative S-adenosyl-L-methionine-dependent methyltransferase; Putative biotin synthesis protein; Protein involved in biotin biosynthetic process; Belongs to the methyltransferase superfamily. | Putative methyltransferase; Protein involved in RNA modification; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | 0.735 |
yafE | ymfD | b0210 | b1137 | Putative S-adenosyl-L-methionine-dependent methyltransferase; Putative biotin synthesis protein; Protein involved in biotin biosynthetic process; Belongs to the methyltransferase superfamily. | E14 prophage; putative SAM-dependent methyltransferase. | 0.748 |
yafS | gloB | b0213 | b0212 | Putative S-adenosyl-L-methionine-dependent methyltransferase. | Hydroxyacylglutathione hydrolase; Type II glyoxalase that catalyzes the hydrolysis of (R)-S- lactoylglutathione to (R)-lactate and glutathione. Is more efficient than the isozyme GloC, and plays a major contribution to methylglyoxal (MG) detoxification in E.coli. The two isoenzymes have additive effects and ensure maximal MG degradation. | 0.851 |
yafS | mltD | b0213 | b0211 | Putative S-adenosyl-L-methionine-dependent methyltransferase. | Putative membrane-bound lytic murein transglycosylase D; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity); Belongs to the transglycosylase Slt family. | 0.709 |
yafS | rseB | b0213 | b2571 | Putative S-adenosyl-L-methionine-dependent methyltransferase. | Anti-sigma E factor, binds RseA; Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS, which is probably relieved by lipopolysaccharide binding (LPS). Belongs to the RseB family. | 0.751 |
yafS | smtA | b0213 | b0921 | Putative S-adenosyl-L-methionine-dependent methyltransferase. | Putative S-adenosyl-L-methionine-dependent methyltransferase; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs. Four tRNAs (tRNA(Ala1), tRNA(Ser1), tRNA(Pro3) and tRNA(Thr4)) are fully modified with mcmo5U in stationary-phase E.coli. Also present at low frequency in tRNA(Leu3) and tRNA(Val1). | 0.668 |
yafS | yafE | b0213 | b0210 | Putative S-adenosyl-L-methionine-dependent methyltransferase. | Putative S-adenosyl-L-methionine-dependent methyltransferase; Putative biotin synthesis protein; Protein involved in biotin biosynthetic process; Belongs to the methyltransferase superfamily. | 0.905 |