node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
betA | betB | b0311 | b0312 | Choline dehydrogenase, a flavoprotein; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. Belongs to the GMC oxidoreductase family. | Betaine aldehyde dehydrogenase, NAD-dependent; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. It is highly specific for betaine and has a significantly higher affinity for NAD than for NADP. | 0.999 |
betA | betI | b0311 | b0313 | Choline dehydrogenase, a flavoprotein; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. Belongs to the GMC oxidoreductase family. | Choline-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. | 0.997 |
betA | betT | b0311 | b0314 | Choline dehydrogenase, a flavoprotein; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. Belongs to the GMC oxidoreductase family. | Choline transporter of high affinity; High-affinity uptake of choline driven by a proton-motive force; Belongs to the BCCT transporter (TC 2.A.15) family. | 0.987 |
betB | betA | b0312 | b0311 | Betaine aldehyde dehydrogenase, NAD-dependent; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. It is highly specific for betaine and has a significantly higher affinity for NAD than for NADP. | Choline dehydrogenase, a flavoprotein; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. Belongs to the GMC oxidoreductase family. | 0.999 |
betB | betI | b0312 | b0313 | Betaine aldehyde dehydrogenase, NAD-dependent; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. It is highly specific for betaine and has a significantly higher affinity for NAD than for NADP. | Choline-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. | 0.998 |
betB | betT | b0312 | b0314 | Betaine aldehyde dehydrogenase, NAD-dependent; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. It is highly specific for betaine and has a significantly higher affinity for NAD than for NADP. | Choline transporter of high affinity; High-affinity uptake of choline driven by a proton-motive force; Belongs to the BCCT transporter (TC 2.A.15) family. | 0.982 |
betI | betA | b0313 | b0311 | Choline-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. | Choline dehydrogenase, a flavoprotein; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. Belongs to the GMC oxidoreductase family. | 0.997 |
betI | betB | b0313 | b0312 | Choline-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. | Betaine aldehyde dehydrogenase, NAD-dependent; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. It is highly specific for betaine and has a significantly higher affinity for NAD than for NADP. | 0.998 |
betI | betT | b0313 | b0314 | Choline-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. | Choline transporter of high affinity; High-affinity uptake of choline driven by a proton-motive force; Belongs to the BCCT transporter (TC 2.A.15) family. | 0.990 |
betI | cynR | b0313 | b0338 | Choline-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. | Transcriptional activator of cyn operon; Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region. | 0.594 |
betI | nanR | b0313 | b3226 | Choline-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. | Sialic acid-inducible nan operon repressor; Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids. Represses expression of the nanATEK- yhcH, nanCMS and yjhBC operons. Acts by binding directly to the Nan box, a region of approximately 30 bp covering the promoter region. | 0.530 |
betI | patD | b0313 | b1444 | Choline-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. | Gamma-aminobutyraldehyde dehydrogenase; Catalyzes the oxidation 4-aminobutanal (gamma- aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal, which allows E.coli to grow on putrescine as the sole nitrogen source. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Can also oxidize n-alkyl medium-chain aldehydes, bu [...] | 0.468 |
betI | puuC | b0313 | b1300 | Choline-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. | Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Catalyzes the oxidation of 3-hydroxypropionaldehyde (3-HPA) to 3-hydroxypropionic acid (3-HP). It acts preferentially with NAD but can also use NADP. 3-HPA appears to be the most suitable substrate for PuuC followed by isovaleraldehyde, propionaldehyde, butyraldehyde, and valeraldehyde. It might play a role in propionate and/or acetic acid metabolisms. Also involved in the breakdown of putrescine through the oxidation of gamma-Glu-gamma-aminobutyraldehyde to gamma-Glu-gamma-aminobutyrate (gamma-Glu-GABA). | 0.459 |
betI | rutR | b0313 | b1013 | Choline-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. | Rut operon transcriptional repressor for; Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX). | 0.609 |
betI | ulaR | b0313 | b4191 | Choline-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. | Transcriptional repressor for the L-ascorbate utilization divergent operon; Represses ulaG and the ulaABCDEF operon. Two ulaR binding sites have been identified in each promoter. Full activity requires simultaneous interaction of UlaR with both divergent promoters and seems to be dependent on repressor-mediated DNA loop formation, which is helped by the action of integration host factor. | 0.591 |
betI | ybiH | b0313 | b0796 | Choline-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. | DUF1956 domain-containing tetR family putative transcriptional regulator; Regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol. Represses the cecR-ybhGFSR operon and activates the rhlE operon. Acts by binding to a palindromic sequence within the intergenic spacer located between these two divergently transcribed operons. | 0.516 |
betT | betA | b0314 | b0311 | Choline transporter of high affinity; High-affinity uptake of choline driven by a proton-motive force; Belongs to the BCCT transporter (TC 2.A.15) family. | Choline dehydrogenase, a flavoprotein; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. Belongs to the GMC oxidoreductase family. | 0.987 |
betT | betB | b0314 | b0312 | Choline transporter of high affinity; High-affinity uptake of choline driven by a proton-motive force; Belongs to the BCCT transporter (TC 2.A.15) family. | Betaine aldehyde dehydrogenase, NAD-dependent; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. It is highly specific for betaine and has a significantly higher affinity for NAD than for NADP. | 0.982 |
betT | betI | b0314 | b0313 | Choline transporter of high affinity; High-affinity uptake of choline driven by a proton-motive force; Belongs to the BCCT transporter (TC 2.A.15) family. | Choline-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. | 0.990 |
cynR | betI | b0338 | b0313 | Transcriptional activator of cyn operon; Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region. | Choline-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. | 0.594 |