STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cynTCarbonic anhydrase; Reversible hydration of carbon dioxide. Carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (CynS) diffuses out of the cell faster than it would be hydrated to bicarbonate, so the apparent function of this enzyme is to catalyze the hydration of carbon dioxide and thus prevent depletion of cellular bicarbonate. (219 aa)    
Predicted Functional Partners:
cynS
Cyanate aminohydrolase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
 
 
 0.998
can
Putative carbonic anhdrase; Belongs to the beta-class carbonic anhydrase family.
  
  
0.943
cynX
Putative cyanate transporter; This protein is part of an active transport system that transports exogenous cyanate into E.coli cells; Belongs to the major facilitator superfamily. Cyanate porter (TC 2.A.1.17) family.
  
  
 0.930
dauA
C4-dicarboxylic acid transporter; Responsible for the aerobic transport of succinate from the periplasm to the cytoplasm at acidic pH. Can transport other C4- dicarboxylic acids such as aspartate and fumarate. May also play a role in the regulation of C4-dicarboxylic acid metabolism at pH 7, via regulation of expression and/or activity of DctA. May act as a co- sensor of DcuS.
 
  
 0.925
cynR
Transcriptional activator of cyn operon; Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region.
 
  
 0.893
caiE
Stimulator of CaiD and CaiB enzyme activities; Overproduction of CaiE stimulates the activity of CaiB and CaiD; Belongs to the transferase hexapeptide repeat family.
    
 
 0.589
yrdA
Bacterial transferase hexapeptide domain protein; Putative transferase; Belongs to the gamma-class carbonic anhydrase family.
    
 
 0.549
yeaD
D-hexose-6-phosphate epimerase-like protein; Belongs to the glucose-6-phosphate 1-epimerase family.
  
   
 0.502
focA
Formate channel; Involved in the bidirectional transport of formate; Belongs to the FNT transporter (TC 2.A.44) family.
  
    0.472
yfdC
Putative transport protein.
  
    0.472
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.