node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
copA | frmR | b0484 | b0357 | Copper transporter; [Copper-exporting P-type ATPase]: Exports Cu(+) from the cytoplasm to the periplasm. Binds 2 Cu(+) ions per monomer, which are transferred to periplasmic copper chaperone CusF upon ATP hydrolysis. In vitro an excess of CusF over CopA is required for efficient transfer. May also be involved in silver export. | Regulator protein that represses frmRAB operon; Repressor of the frmRAB operon. | 0.631 |
copA | zntR | b0484 | b3292 | Copper transporter; [Copper-exporting P-type ATPase]: Exports Cu(+) from the cytoplasm to the periplasm. Binds 2 Cu(+) ions per monomer, which are transferred to periplasmic copper chaperone CusF upon ATP hydrolysis. In vitro an excess of CusF over CopA is required for efficient transfer. May also be involved in silver export. | zntA gene transcriptional activator; Zinc-responsive transcriptional regulator of zntA. | 0.541 |
frmA | frmB | b0356 | b0355 | Alcohol dehydrogenase class III; Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent. In addition, hemithiolacetals other than those formed from GSH, including omega-thiol fatty acids, also are substrates; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against two pNP-esters (pNP- acetate and pNP-propionate), alpha-naphthyl acetate and lactoylglutathione. | 0.999 |
frmA | frmR | b0356 | b0357 | Alcohol dehydrogenase class III; Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent. In addition, hemithiolacetals other than those formed from GSH, including omega-thiol fatty acids, also are substrates; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | Regulator protein that represses frmRAB operon; Repressor of the frmRAB operon. | 0.997 |
frmA | yeiG | b0356 | b2154 | Alcohol dehydrogenase class III; Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent. In addition, hemithiolacetals other than those formed from GSH, including omega-thiol fatty acids, also are substrates; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against alpha-naphthyl acetate, lactoylglutathione, palmitoyl-CoA and several pNP-esters of short chain fatty acids. | 0.999 |
frmB | frmA | b0355 | b0356 | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against two pNP-esters (pNP- acetate and pNP-propionate), alpha-naphthyl acetate and lactoylglutathione. | Alcohol dehydrogenase class III; Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent. In addition, hemithiolacetals other than those formed from GSH, including omega-thiol fatty acids, also are substrates; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | 0.999 |
frmB | frmR | b0355 | b0357 | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against two pNP-esters (pNP- acetate and pNP-propionate), alpha-naphthyl acetate and lactoylglutathione. | Regulator protein that represses frmRAB operon; Repressor of the frmRAB operon. | 0.991 |
frmB | yeiG | b0355 | b2154 | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against two pNP-esters (pNP- acetate and pNP-propionate), alpha-naphthyl acetate and lactoylglutathione. | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against alpha-naphthyl acetate, lactoylglutathione, palmitoyl-CoA and several pNP-esters of short chain fatty acids. | 0.914 |
frmR | copA | b0357 | b0484 | Regulator protein that represses frmRAB operon; Repressor of the frmRAB operon. | Copper transporter; [Copper-exporting P-type ATPase]: Exports Cu(+) from the cytoplasm to the periplasm. Binds 2 Cu(+) ions per monomer, which are transferred to periplasmic copper chaperone CusF upon ATP hydrolysis. In vitro an excess of CusF over CopA is required for efficient transfer. May also be involved in silver export. | 0.631 |
frmR | frmA | b0357 | b0356 | Regulator protein that represses frmRAB operon; Repressor of the frmRAB operon. | Alcohol dehydrogenase class III; Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent. In addition, hemithiolacetals other than those formed from GSH, including omega-thiol fatty acids, also are substrates; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | 0.997 |
frmR | frmB | b0357 | b0355 | Regulator protein that represses frmRAB operon; Repressor of the frmRAB operon. | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against two pNP-esters (pNP- acetate and pNP-propionate), alpha-naphthyl acetate and lactoylglutathione. | 0.991 |
frmR | psuK | b0357 | b2166 | Regulator protein that represses frmRAB operon; Repressor of the frmRAB operon. | Pseudouridine kinase; Catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP). | 0.601 |
frmR | rcnA | b0357 | b2106 | Regulator protein that represses frmRAB operon; Repressor of the frmRAB operon. | Membrane protein conferring nickel and cobalt resistance; Efflux system for nickel and cobalt. | 0.489 |
frmR | yaiO | b0357 | b0358 | Regulator protein that represses frmRAB operon; Repressor of the frmRAB operon. | Outer membrane protein. | 0.586 |
frmR | ybeL | b0357 | b0643 | Regulator protein that represses frmRAB operon; Repressor of the frmRAB operon. | DUF1451 family protein; Putative alpha helical protein. | 0.811 |
frmR | yeiG | b0357 | b2154 | Regulator protein that represses frmRAB operon; Repressor of the frmRAB operon. | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against alpha-naphthyl acetate, lactoylglutathione, palmitoyl-CoA and several pNP-esters of short chain fatty acids. | 0.657 |
frmR | yobD | b0357 | b1820 | Regulator protein that represses frmRAB operon; Repressor of the frmRAB operon. | UPF0266 family inner membrane protein. | 0.505 |
frmR | zntR | b0357 | b3292 | Regulator protein that represses frmRAB operon; Repressor of the frmRAB operon. | zntA gene transcriptional activator; Zinc-responsive transcriptional regulator of zntA. | 0.454 |
psuK | frmR | b2166 | b0357 | Pseudouridine kinase; Catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP). | Regulator protein that represses frmRAB operon; Repressor of the frmRAB operon. | 0.601 |
psuK | yobD | b2166 | b1820 | Pseudouridine kinase; Catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP). | UPF0266 family inner membrane protein. | 0.622 |