node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
higA | higB | b3082 | b3083 | Antitoxinof the HigB-HigA toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin; overexpression prevents HigB-mediated cessation of cell growth and inhibition of cell proliferation. | mRNA interferase toxin of the HigB-HigA toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase. mRNA interferases play a role in bacterial persistence to antibiotics; overexpression of this protein induces p [...] | 0.999 |
higA | ybaQ | b3082 | b0483 | Antitoxinof the HigB-HigA toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin; overexpression prevents HigB-mediated cessation of cell growth and inhibition of cell proliferation. | Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. | 0.682 |
higA | yddM | b3082 | b1477 | Antitoxinof the HigB-HigA toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin; overexpression prevents HigB-mediated cessation of cell growth and inhibition of cell proliferation. | Putative DNA-binding transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent; Belongs to the VapA/VapI family. | 0.456 |
higB | higA | b3083 | b3082 | mRNA interferase toxin of the HigB-HigA toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase. mRNA interferases play a role in bacterial persistence to antibiotics; overexpression of this protein induces p [...] | Antitoxinof the HigB-HigA toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin; overexpression prevents HigB-mediated cessation of cell growth and inhibition of cell proliferation. | 0.999 |
higB | ybaQ | b3083 | b0483 | mRNA interferase toxin of the HigB-HigA toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase. mRNA interferases play a role in bacterial persistence to antibiotics; overexpression of this protein induces p [...] | Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. | 0.501 |
ybaP | ybaQ | b0482 | b0483 | TraB family protein; Putative ligase. | Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. | 0.828 |
ybaQ | higA | b0483 | b3082 | Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. | Antitoxinof the HigB-HigA toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin; overexpression prevents HigB-mediated cessation of cell growth and inhibition of cell proliferation. | 0.682 |
ybaQ | higB | b0483 | b3083 | Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. | mRNA interferase toxin of the HigB-HigA toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase. mRNA interferases play a role in bacterial persistence to antibiotics; overexpression of this protein induces p [...] | 0.501 |
ybaQ | ybaP | b0483 | b0482 | Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. | TraB family protein; Putative ligase. | 0.828 |
ybaQ | ybiH | b0483 | b0796 | Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. | DUF1956 domain-containing tetR family putative transcriptional regulator; Regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol. Represses the cecR-ybhGFSR operon and activates the rhlE operon. Acts by binding to a palindromic sequence within the intergenic spacer located between these two divergently transcribed operons. | 0.439 |
ybaQ | ydcI | b0483 | b1422 | Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. | 0.472 |
ybaQ | yddM | b0483 | b1477 | Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. | Putative DNA-binding transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent; Belongs to the VapA/VapI family. | 0.443 |
ybaQ | yeiE | b0483 | b2157 | Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. | 0.622 |
ybaQ | yfeC | b0483 | b2398 | Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. | DUF1323 family putative DNA-binding protein; To E.coli YfiI and P.aeruginosa RluD. | 0.516 |
ybaQ | yfeD | b0483 | b2399 | Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. | DUF1323 family putative DNA-binding protein. | 0.512 |
ybaQ | yieP | b0483 | b3755 | Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. | Putative transcriptional regulator. | 0.454 |
ybiH | ybaQ | b0796 | b0483 | DUF1956 domain-containing tetR family putative transcriptional regulator; Regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol. Represses the cecR-ybhGFSR operon and activates the rhlE operon. Acts by binding to a palindromic sequence within the intergenic spacer located between these two divergently transcribed operons. | Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. | 0.439 |
ybiH | ydcI | b0796 | b1422 | DUF1956 domain-containing tetR family putative transcriptional regulator; Regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol. Represses the cecR-ybhGFSR operon and activates the rhlE operon. Acts by binding to a palindromic sequence within the intergenic spacer located between these two divergently transcribed operons. | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. | 0.511 |
ybiH | yddM | b0796 | b1477 | DUF1956 domain-containing tetR family putative transcriptional regulator; Regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol. Represses the cecR-ybhGFSR operon and activates the rhlE operon. Acts by binding to a palindromic sequence within the intergenic spacer located between these two divergently transcribed operons. | Putative DNA-binding transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent; Belongs to the VapA/VapI family. | 0.490 |
ybiH | yeiE | b0796 | b2157 | DUF1956 domain-containing tetR family putative transcriptional regulator; Regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol. Represses the cecR-ybhGFSR operon and activates the rhlE operon. Acts by binding to a palindromic sequence within the intergenic spacer located between these two divergently transcribed operons. | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. | 0.483 |