node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
allB | garK | b0512 | b3124 | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | Glycerate kinase I; Protein involved in carbohydrate catabolic process; Belongs to the glycerate kinase type-1 family. | 0.762 |
allB | gcl | b0512 | b0507 | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | Glyoxylate carboligase; Catalyzes the condensation of two molecules of glyoxylate to give 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). | 0.754 |
allB | glxK | b0512 | b0514 | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | Glycerate kinase II; Protein involved in carbohydrate catabolic process, glycolate metabolic process and allantoin assimilation pathway; Belongs to the glycerate kinase type-1 family. | 0.955 |
allB | glxR | b0512 | b0509 | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | Tartronate semialdehyde reductase, NADH-dependent; Protein involved in carbohydrate catabolic process, glycolate metabolic process and allantoin assimilation pathway; Belongs to the HIBADH-related family. | 0.779 |
allB | hyi | b0512 | b0508 | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | Hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). Does not catalyze the isomerization of D-fructose to D- glucose or that of D-xylulose to D-xylose. Also does not catalyze racemization of serine, alanine, glycerate or lactate. | 0.769 |
argP | garR | b2916 | b3125 | HTH-type transcriptional regulator ArgP; Controls the transcription of genes involved in arginine and lysine metabolism. Activates transcription of several genes, including argO, lysP, lysC, asd, dapB, dapD, lysA, gdhA and argK. Acts by binding directly to their promoter or control region. ArgP dimer by itself is able to bind the argO promoter-operator region to form a binary complex, but the formation of a ternary complex with RNA polymerase is greatly stimulated only in presence of a coeffector. Both arginine and lysine are coeffectors at the argO promoter, but only arginine is compe [...] | Tartronate semialdehyde reductase; Catalyzes the reduction of tatronate semialdehyde to D- glycerate. | 0.809 |
argP | glxR | b2916 | b0509 | HTH-type transcriptional regulator ArgP; Controls the transcription of genes involved in arginine and lysine metabolism. Activates transcription of several genes, including argO, lysP, lysC, asd, dapB, dapD, lysA, gdhA and argK. Acts by binding directly to their promoter or control region. ArgP dimer by itself is able to bind the argO promoter-operator region to form a binary complex, but the formation of a ternary complex with RNA polymerase is greatly stimulated only in presence of a coeffector. Both arginine and lysine are coeffectors at the argO promoter, but only arginine is compe [...] | Tartronate semialdehyde reductase, NADH-dependent; Protein involved in carbohydrate catabolic process, glycolate metabolic process and allantoin assimilation pathway; Belongs to the HIBADH-related family. | 0.786 |
garK | allB | b3124 | b0512 | Glycerate kinase I; Protein involved in carbohydrate catabolic process; Belongs to the glycerate kinase type-1 family. | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | 0.762 |
garK | garL | b3124 | b3126 | Glycerate kinase I; Protein involved in carbohydrate catabolic process; Belongs to the glycerate kinase type-1 family. | alpha-dehydro-beta-deoxy-D-glucarate aldolase; Catalyzes the reversible retro-aldol cleavage of both 5-keto- 4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde; Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily. | 0.792 |
garK | garR | b3124 | b3125 | Glycerate kinase I; Protein involved in carbohydrate catabolic process; Belongs to the glycerate kinase type-1 family. | Tartronate semialdehyde reductase; Catalyzes the reduction of tatronate semialdehyde to D- glycerate. | 0.984 |
garK | ghrA | b3124 | b1033 | Glycerate kinase I; Protein involved in carbohydrate catabolic process; Belongs to the glycerate kinase type-1 family. | Glyoxylate/hydroxypyruvate reductase A; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Inactive towards 2-oxo-D-gluconate, 2-oxoglutarate, oxaloacetate and pyruvate. Only D- and L-glycerate are involved in the oxidative activity with NADP. Activity with NAD is very low. | 0.900 |
garK | ghrB | b3124 | b3553 | Glycerate kinase I; Protein involved in carbohydrate catabolic process; Belongs to the glycerate kinase type-1 family. | Glyoxylate/hydroxypyruvate reductase B; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Can also reduce 2,5-diketo-D-gluconate (25DKG) to 5-keto-D-gluconate (5KDG), 2- keto-D-gluconate (2KDG) to D-gluconate, and 2-keto-L-gulonate (2KLG) to L-idonate (IA), but it is not its physiological function. Inactive towards 2-oxoglutarate, oxaloacetate, pyruvate, 5-keto-D-gluconate, D- fructose and L-sorbose. Activity with NAD is very low; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. | 0.909 |
garK | glxK | b3124 | b0514 | Glycerate kinase I; Protein involved in carbohydrate catabolic process; Belongs to the glycerate kinase type-1 family. | Glycerate kinase II; Protein involved in carbohydrate catabolic process, glycolate metabolic process and allantoin assimilation pathway; Belongs to the glycerate kinase type-1 family. | 0.908 |
garK | glxR | b3124 | b0509 | Glycerate kinase I; Protein involved in carbohydrate catabolic process; Belongs to the glycerate kinase type-1 family. | Tartronate semialdehyde reductase, NADH-dependent; Protein involved in carbohydrate catabolic process, glycolate metabolic process and allantoin assimilation pathway; Belongs to the HIBADH-related family. | 0.946 |
garL | garK | b3126 | b3124 | alpha-dehydro-beta-deoxy-D-glucarate aldolase; Catalyzes the reversible retro-aldol cleavage of both 5-keto- 4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde; Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily. | Glycerate kinase I; Protein involved in carbohydrate catabolic process; Belongs to the glycerate kinase type-1 family. | 0.792 |
garL | garR | b3126 | b3125 | alpha-dehydro-beta-deoxy-D-glucarate aldolase; Catalyzes the reversible retro-aldol cleavage of both 5-keto- 4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde; Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily. | Tartronate semialdehyde reductase; Catalyzes the reduction of tatronate semialdehyde to D- glycerate. | 0.999 |
garL | gcl | b3126 | b0507 | alpha-dehydro-beta-deoxy-D-glucarate aldolase; Catalyzes the reversible retro-aldol cleavage of both 5-keto- 4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde; Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily. | Glyoxylate carboligase; Catalyzes the condensation of two molecules of glyoxylate to give 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). | 0.800 |
garL | glxR | b3126 | b0509 | alpha-dehydro-beta-deoxy-D-glucarate aldolase; Catalyzes the reversible retro-aldol cleavage of both 5-keto- 4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde; Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily. | Tartronate semialdehyde reductase, NADH-dependent; Protein involved in carbohydrate catabolic process, glycolate metabolic process and allantoin assimilation pathway; Belongs to the HIBADH-related family. | 0.918 |
garL | hyi | b3126 | b0508 | alpha-dehydro-beta-deoxy-D-glucarate aldolase; Catalyzes the reversible retro-aldol cleavage of both 5-keto- 4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde; Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily. | Hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). Does not catalyze the isomerization of D-fructose to D- glucose or that of D-xylulose to D-xylose. Also does not catalyze racemization of serine, alanine, glycerate or lactate. | 0.800 |
garR | argP | b3125 | b2916 | Tartronate semialdehyde reductase; Catalyzes the reduction of tatronate semialdehyde to D- glycerate. | HTH-type transcriptional regulator ArgP; Controls the transcription of genes involved in arginine and lysine metabolism. Activates transcription of several genes, including argO, lysP, lysC, asd, dapB, dapD, lysA, gdhA and argK. Acts by binding directly to their promoter or control region. ArgP dimer by itself is able to bind the argO promoter-operator region to form a binary complex, but the formation of a ternary complex with RNA polymerase is greatly stimulated only in presence of a coeffector. Both arginine and lysine are coeffectors at the argO promoter, but only arginine is compe [...] | 0.809 |