STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the AIR carboxylase family. Class I subfamily. (169 aa)    
Predicted Functional Partners:
purK
N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family.
 
 0.999
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase; Protein involved in purine nucleotide biosynthetic process.
 
 0.999
purM
Phosphoribosylaminoimidazole synthetase = AIR synthetase; Protein involved in purine nucleotide biosynthetic process; Belongs to the AIR synthase family.
 
  
 0.999
purL
Phosphoribosylformyl-glycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
 
  
 0.999
purD
Phosphoribosylglycinamide synthetase = GAR synthetase; Protein involved in purine nucleotide biosynthetic process; Belongs to the GARS family.
  
 0.999
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. Can also use NH(3) in place of glutamine.
 
  
 0.998
purN
Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate; Belongs to the GART family.
 
  
 0.998
purH
IMP cyclohydrolase and phosphoribosylaminoimidazolecarboxamide formyltransferase; Protein involved in purine nucleotide biosynthetic process and nucleobase, nucleoside and nucleotide interconversion.
 
  
 0.998
purT
Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. PurT is also able to cleave acetyl phosphate and carbamoyl phosphate to produce ATP with acetate and carbamate, respectively; Belongs to the PurK/PurT family.
  
 0.992
purB
Adenylosuccinate lyase; Protein involved in purine nucleotide biosynthetic process; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
  
 0.980
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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