STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
modCMolybdate ABC transporter ATPase; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. (352 aa)    
Predicted Functional Partners:
modA
Molybdate ABC transporter periplasmic binding protein; Part of the ABC transporter complex ModABC involved in the transport of molybdenum into the cell. Binds molybdate with high affinity in vitro and with a similar affinity in vivo. Binds tungstate with high affinity in vitro. Binds unnatural anion perrhenate with high affinity in vitro. Does not bind sulfate, phosphate, arsenate, selenate, chlorate, metavanadate, nitrate, perchlorate, permanganate or carbonate. Belongs to the bacterial solute-binding protein ModA family.
 
 0.999
modB
Molybdate ABC transporter permease; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
 
 0.999
modE
Transcriptional repressor for the molybdenum transport operon modABC; Functions as an intracellular molybdate sensor. The ModE-Mo complex acts as a repressor of the modABC operon, which is involved in the transport of molybdate. Binds modA promoter DNA in the absence of molybdate, however molybdate binding confers increased DNA affinity. Binds the promoter of moaA activating its transcription; binding is not enhanced by molybdate. The protein dimer binds the consensus palindrome sequence 5'-TATAT-N7-TAYAT-3' and a variant 5'-TGTGT-N7-TGYGT-3'. Acts as a regulator of the expression of 6 [...]
 
 
 
 0.952
moeA
Molybdopterin molybdenumtransferase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.
   
 0.920
modF
Molybdate ABC transporter ATPase; Probably not involved in the transport of molybdenum into the cell; Belongs to the ABC transporter superfamily.
    
0.867
dppD
Dipeptide/heme ABC transporter ATPas; Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system.
 
 
 
0.817
ddpD
D,D-dipeptide ABC transporter ATPase; Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for energy coupling to the transport system.
 
 
 
 
0.776
moaA
Molybdopterin biosynthesis protein A; Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z).
     
 0.763
nikD
Nickel ABC transporter ATPase; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
 
 
 
0.757
moaE
Molybdopterin synthase, large subunit; Converts molybdopterin precursor Z to molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD.
 
   
 0.733
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.