STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mntRMn(2+)-responsive manganese regulon transcriptional regulator; In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP. (155 aa)    
Predicted Functional Partners:
mntH
Manganese/divalent cation transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen.
 
  
 0.951
ybiR
Putative transporter.
 
    0.931
mntP
Putative Mn(2+) efflux pump, mntR-regulated; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family.
     
 0.924
mntS
Mn(2)-response protein, MntR-repressed; Required for repression of mntH by MntR. May function as a chaperone that makes manganese more available by delivering it to the necessary cellular locations when manganese is limiting.
     
 0.909
hycG
Hydrogenase 3 and formate hydrogenase complex, HycG subunit; Hydrogenase activity; Protein involved in fermentation and anaerobic respiration.
    
 
 0.853
metN
DL-methionine transporter subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. It has also been shown to be involved in formyl-L-methionine transport. Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
    
   0.850
perR
CP4-6 prophage; Apparent regulatory gene involved in peroxide resistance in stationary phase; Belongs to the LysR transcriptional regulatory family.
    
 
 0.841
zupT
Zinc transporter; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions; Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
  
  
 0.801
yfcH
Putative sugar nucleotide epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.
   
    0.749
rcnR
Transcriptional repressor of rcnA; Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter. Belongs to the FrmR/RcnR family.
   
  
 0.748
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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