STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdtHMultidrug resistance protein MdtH; Confers resistance to norfloxacin and enoxacin. (402 aa)    
Predicted Functional Partners:
mdtG
Putative drug efflux system protein; Confers resistance to fosfomycin and deoxycholate. Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily.
   
  
 0.812
mdtL
Multidrug efflux system protein; Confers resistance to chloramphenicol. Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
      
 0.809
mdtK
Multidrug efflux system transporter; Multidrug efflux pump that probably functions as a Na(+)/drug antiporter. Confers resistance to many drugs such as fluoroquinolones (norfloxacin, ciprofloxacin, enoxacin) and tetraphenylphosphonium ion (TPP). Also to deoxycholate, doxorubicin, trimethoprim, chloramphenicol, fosfomycin, ethidium bromide and benzalkonium. Also able to export peptides; when overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing [...]
   
  
 0.806
emrK
Multidrug resistance efflux pump membrane fusion protein; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs.
      
 0.805
mdtM
Multidrug efflux system protein; Confers resistance to acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP; Belongs to the major facilitator superfamily.
   
  
 0.805
emrD
Multidrug efflux system protein; Multidrug resistance pump that participates in a low energy shock adaptive response; Belongs to the major facilitator superfamily.
      
 0.801
mdtA
Multidrug efflux system, subunit A; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function. Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
   
 
 0.797
mdtP
Outer membrane factor of efflux pump; Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
   
  
 0.787
dinI
DNA damage-inducible protein I; Involved in SOS regulation. Inhibits RecA by preventing RecA to bind ssDNA. Can displace ssDNA from RecA.
      0.738
fsr
Putative fosmidomycin efflux system protein; Confers the resistance against fosmidomycin; Belongs to the major facilitator superfamily.
      
 0.733
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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