node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
alx | yciC | b3088 | b1255 | Putative membrane-bound redox modulator; Has been proposed to be a redox modulator. | UPF0259 family inner membrane protein. | 0.426 |
argK | hypB | b2918 | b2727 | Membrane ATPase/protein kinase; Binds and hydrolyzes GTP. Likely functions as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) ScpA and reactivation of the enzyme during catalysis; Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. | GTP hydrolase involved in nickel liganding into hydrogenases; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. In the presence of GDP, nickel, but not zinc, is transferred from the HypB GTPase domain (G-domain) to HypA. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. | 0.814 |
argK | yciC | b2918 | b1255 | Membrane ATPase/protein kinase; Binds and hydrolyzes GTP. Likely functions as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) ScpA and reactivation of the enzyme during catalysis; Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. | UPF0259 family inner membrane protein. | 0.500 |
argK | yeiR | b2918 | b2173 | Membrane ATPase/protein kinase; Binds and hydrolyzes GTP. Likely functions as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) ScpA and reactivation of the enzyme during catalysis; Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. | Zn-stimulated GTPase involved in zinc homeostasis; Involved in metal homeostasis. Has GTPase activity. Binds several Zn(2+) ions in vitro. | 0.739 |
argK | yjiA | b2918 | b4352 | Membrane ATPase/protein kinase; Binds and hydrolyzes GTP. Likely functions as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) ScpA and reactivation of the enzyme during catalysis; Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. | Metal-binding GTPase; Binds GTP and has low GTPase activity. May have a GTP- dependent regulatory function; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | 0.894 |
hypB | argK | b2727 | b2918 | GTP hydrolase involved in nickel liganding into hydrogenases; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. In the presence of GDP, nickel, but not zinc, is transferred from the HypB GTPase domain (G-domain) to HypA. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. | Membrane ATPase/protein kinase; Binds and hydrolyzes GTP. Likely functions as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) ScpA and reactivation of the enzyme during catalysis; Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. | 0.814 |
hypB | yciC | b2727 | b1255 | GTP hydrolase involved in nickel liganding into hydrogenases; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. In the presence of GDP, nickel, but not zinc, is transferred from the HypB GTPase domain (G-domain) to HypA. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. | UPF0259 family inner membrane protein. | 0.527 |
hypB | yeiR | b2727 | b2173 | GTP hydrolase involved in nickel liganding into hydrogenases; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. In the presence of GDP, nickel, but not zinc, is transferred from the HypB GTPase domain (G-domain) to HypA. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. | Zn-stimulated GTPase involved in zinc homeostasis; Involved in metal homeostasis. Has GTPase activity. Binds several Zn(2+) ions in vitro. | 0.665 |
hypB | yjiA | b2727 | b4352 | GTP hydrolase involved in nickel liganding into hydrogenases; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. In the presence of GDP, nickel, but not zinc, is transferred from the HypB GTPase domain (G-domain) to HypA. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. | Metal-binding GTPase; Binds GTP and has low GTPase activity. May have a GTP- dependent regulatory function; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. | 0.905 |
queD | yciC | b2765 | b1255 | 6-pyruvoyl tetrahydrobiopterin synthase (PTPS); Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP. | UPF0259 family inner membrane protein. | 0.406 |
yciA | yciB | b1253 | b1254 | acyl-CoA esterase; Catalyzes the hydrolysis of the thioester bond in palmitoyl- CoA and malonyl-CoA. | IspA family inner membrane protein; Involved in cell division; probably involved in intracellular septation; Belongs to the YciB family. | 0.859 |
yciA | yciC | b1253 | b1255 | acyl-CoA esterase; Catalyzes the hydrolysis of the thioester bond in palmitoyl- CoA and malonyl-CoA. | UPF0259 family inner membrane protein. | 0.955 |
yciB | yciA | b1254 | b1253 | IspA family inner membrane protein; Involved in cell division; probably involved in intracellular septation; Belongs to the YciB family. | acyl-CoA esterase; Catalyzes the hydrolysis of the thioester bond in palmitoyl- CoA and malonyl-CoA. | 0.859 |
yciB | yciC | b1254 | b1255 | IspA family inner membrane protein; Involved in cell division; probably involved in intracellular septation; Belongs to the YciB family. | UPF0259 family inner membrane protein. | 0.973 |
yciC | alx | b1255 | b3088 | UPF0259 family inner membrane protein. | Putative membrane-bound redox modulator; Has been proposed to be a redox modulator. | 0.426 |
yciC | argK | b1255 | b2918 | UPF0259 family inner membrane protein. | Membrane ATPase/protein kinase; Binds and hydrolyzes GTP. Likely functions as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) ScpA and reactivation of the enzyme during catalysis; Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. | 0.500 |
yciC | hypB | b1255 | b2727 | UPF0259 family inner membrane protein. | GTP hydrolase involved in nickel liganding into hydrogenases; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion. In the presence of GDP, nickel, but not zinc, is transferred from the HypB GTPase domain (G-domain) to HypA. Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. | 0.527 |
yciC | queD | b1255 | b2765 | UPF0259 family inner membrane protein. | 6-pyruvoyl tetrahydrobiopterin synthase (PTPS); Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP. | 0.406 |
yciC | yciA | b1255 | b1253 | UPF0259 family inner membrane protein. | acyl-CoA esterase; Catalyzes the hydrolysis of the thioester bond in palmitoyl- CoA and malonyl-CoA. | 0.955 |
yciC | yciB | b1255 | b1254 | UPF0259 family inner membrane protein. | IspA family inner membrane protein; Involved in cell division; probably involved in intracellular septation; Belongs to the YciB family. | 0.973 |