STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uspEStress-induced protein; Required for resistance to DNA-damaging agents. (316 aa)    
Predicted Functional Partners:
uspF
Universal stress protein F; Pseudogene, prophage Rac integration site ttcA duplication;Phage or Prophage Related.
   
  
 0.947
uspG
Universal stress protein UP12; Has intrinsic autoadenylation and autophosphorylation activities, probably on Ser or Thr residues. Belongs to the universal stress protein A family.
   
 
 0.945
uspA
Universal stress global response regulator; Required for resistance to DNA-damaging agents; Belongs to the universal stress protein A family.
  
  
 0.939
fnr
Oxygen-sensing anaerobic growth regulon transcriptional regulator FNR; Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O(2), is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration.
  
 0.927
uspD
Stress-induced protein; Required for resistance to DNA-damaging agents.
   
  
 0.904
uspC
Universal stress protein; Required for resistance to DNA-damaging agents.
   
  
 0.882
ogt
O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
 
  
 0.846
uspB
Protein involved in response to stress and xenobiotic metabolic process.
  
  
 0.839
ynaJ
DUF2534 family putative inner membrane protein.
   
  
 0.769
yfbV
UPF0208 family inner membrane protein.
  
    0.764
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.