STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uspFUniversal stress protein F; Pseudogene, prophage Rac integration site ttcA duplication;Phage or Prophage Related. (144 aa)    
Predicted Functional Partners:
uspE
Stress-induced protein; Required for resistance to DNA-damaging agents.
   
  
 0.947
uspD
Stress-induced protein; Required for resistance to DNA-damaging agents.
   
  
 0.905
uspA
Universal stress global response regulator; Required for resistance to DNA-damaging agents; Belongs to the universal stress protein A family.
   
  
 0.841
uspC
Universal stress protein; Required for resistance to DNA-damaging agents.
   
  
 0.821
uspB
Protein involved in response to stress and xenobiotic metabolic process.
  
  
 0.807
cspD
Inhibitor of DNA replication, cold shock protein homolog; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells.
   
  
 0.774
ychH
DUF2583 family putative inner membrane protein.
   
    0.638
ompN
Outer membrane pore protein N, non-specific; Forms pores that allow passive diffusion of small molecules across the outer membrane (By similarity). Non-specific porin.
     
 0.617
raiA
Cold shock protein associated with 30S ribosomal subunit; During stationary phase prevents 70S dimer formation, probably in order to regulate translation efficiency during transition between the exponential and the stationary phases. During environmental stress such as cold shock or excessive cell density at stationary phase, stabilizes the 70S ribosome against dissociation, inhibits translation elongation and increases translation accuracy. When normal growth conditions are restored, is quickly released from the ribosome. Has been suggested to inhibit translation elongation by blockin [...]
   
  
 0.499
wrbA
NAD(P)H:quinone oxidoreductase; It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide. It prefers NADH over NADPH.
   
  
 0.446
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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