STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ydcRMulti modular; putative transcriptional regulator; also putative ATP-binding component of a transport system; Protein involved in ATP-binding cassette (ABC) transporter activity and regulation of transcription, DNA-dependent; In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (468 aa)    
Predicted Functional Partners:
hicB
Antitoxin for the HicAB toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin; overexpression prevents HicA-mediated cessation of cell growth and inhibition of cell proliferation.
  
  
 0.644
ydbL
DUF1318 family protein.
      
 0.510
yafK
L,D-transpeptidase-related protein.
  
   
 0.467
ybeR
Uncharacterized protein; To E.coli YbeU.
      
 0.462
hicA
mRNA interferase toxin of the HicAB toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-independent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome (after 90 minutes) by subsequent expression of antitoxin HicB. Overexpression causes cleavage of a number of mRNAs and tmRNA, in a translation-independent fashion, suggesting this is an mRNA interferase. mRNA interferases play a role in bacterial persistence to antibiotics ; Belongs t [...]
       0.458
yeeZ
Putative enzyme of sugar metabolism; Protein involved in carbohydrate catabolic process.
      
 0.457
yijF
DUF1287 family protein.
     
 0.453
yehP
VMA domain putative YehL ATPase stimulator.
      
 0.451
ydcS
Putative ABC transporter periplasmic binding protein; Catalyzes the formation of short polymers of R-3- hydroxybutyrate (cPHB). Involved in natural transformation. Probably part of the ABC transporter complex YdcSTUV. During natural transformation, may bind dsDNA and convey it to the inner membrane channel formed by YdcV (Probable). Belongs to the bacterial solute-binding protein PotD/PotF family.
       0.426
ypjA
Adhesin-like autotransporter; Putative ATP-binding component of a transport system.
  
   
 0.424
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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