node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
bcsC | tam | b3530 | b1519 | Cellulose synthase subunit; Required for maximal bacterial cellulose synthesis. | Trans-aconitate methyltransferase; Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate at high affinity and of cis-aconitate, isocitrate, and citrate at lower velocities and affinities; Belongs to the methyltransferase superfamily. Tam family. | 0.737 |
lsrA | lsrB | b1513 | b1516 | Autoinducer 2 import ATP-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (Probable). This protein is essential for aerobic growth. | Autoinducer 2-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable); Belongs to the bacterial solute-binding protein 2 family. | 0.999 |
lsrA | lsrC | b1513 | b1514 | Autoinducer 2 import ATP-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (Probable). This protein is essential for aerobic growth. | Autoinducer 2 import system permease protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable). Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. | 0.999 |
lsrA | lsrD | b1513 | b1515 | Autoinducer 2 import ATP-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (Probable). This protein is essential for aerobic growth. | Autoinducer 2 import system permease protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable). Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. | 0.999 |
lsrA | lsrF | b1513 | b1517 | Autoinducer 2 import ATP-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (Probable). This protein is essential for aerobic growth. | Putative autoinducer-2 (AI-2) aldolase; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA; Belongs to the DeoC/FbaB aldolase family. | 0.992 |
lsrA | lsrG | b1513 | b1518 | Autoinducer 2 import ATP-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (Probable). This protein is essential for aerobic growth. | Autoinducer-2 (AI-2) degrading protein LsrG; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD). | 0.989 |
lsrA | lsrK | b1513 | b1511 | Autoinducer 2 import ATP-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (Probable). This protein is essential for aerobic growth. | Autoinducer-2 kinase; Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position. Required for the regulation of the lsr operon and many other genes. | 0.975 |
lsrA | lsrR | b1513 | b1512 | Autoinducer 2 import ATP-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (Probable). This protein is essential for aerobic growth. | Lsr operon transcriptional repressor; Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes. | 0.985 |
lsrA | tam | b1513 | b1519 | Autoinducer 2 import ATP-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (Probable). This protein is essential for aerobic growth. | Trans-aconitate methyltransferase; Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate at high affinity and of cis-aconitate, isocitrate, and citrate at lower velocities and affinities; Belongs to the methyltransferase superfamily. Tam family. | 0.742 |
lsrB | lsrA | b1516 | b1513 | Autoinducer 2-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable); Belongs to the bacterial solute-binding protein 2 family. | Autoinducer 2 import ATP-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (Probable). This protein is essential for aerobic growth. | 0.999 |
lsrB | lsrC | b1516 | b1514 | Autoinducer 2-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable); Belongs to the bacterial solute-binding protein 2 family. | Autoinducer 2 import system permease protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable). Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. | 0.999 |
lsrB | lsrD | b1516 | b1515 | Autoinducer 2-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable); Belongs to the bacterial solute-binding protein 2 family. | Autoinducer 2 import system permease protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable). Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. | 0.999 |
lsrB | lsrF | b1516 | b1517 | Autoinducer 2-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable); Belongs to the bacterial solute-binding protein 2 family. | Putative autoinducer-2 (AI-2) aldolase; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA; Belongs to the DeoC/FbaB aldolase family. | 0.999 |
lsrB | lsrG | b1516 | b1518 | Autoinducer 2-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable); Belongs to the bacterial solute-binding protein 2 family. | Autoinducer-2 (AI-2) degrading protein LsrG; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD). | 0.999 |
lsrB | lsrK | b1516 | b1511 | Autoinducer 2-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable); Belongs to the bacterial solute-binding protein 2 family. | Autoinducer-2 kinase; Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position. Required for the regulation of the lsr operon and many other genes. | 0.995 |
lsrB | lsrR | b1516 | b1512 | Autoinducer 2-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable); Belongs to the bacterial solute-binding protein 2 family. | Lsr operon transcriptional repressor; Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes. | 0.995 |
lsrB | tam | b1516 | b1519 | Autoinducer 2-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable); Belongs to the bacterial solute-binding protein 2 family. | Trans-aconitate methyltransferase; Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate at high affinity and of cis-aconitate, isocitrate, and citrate at lower velocities and affinities; Belongs to the methyltransferase superfamily. Tam family. | 0.775 |
lsrC | lsrA | b1514 | b1513 | Autoinducer 2 import system permease protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable). Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. | Autoinducer 2 import ATP-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (Probable). This protein is essential for aerobic growth. | 0.999 |
lsrC | lsrB | b1514 | b1516 | Autoinducer 2 import system permease protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable). Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. | Autoinducer 2-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable); Belongs to the bacterial solute-binding protein 2 family. | 0.999 |
lsrC | lsrD | b1514 | b1515 | Autoinducer 2 import system permease protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable). Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. | Autoinducer 2 import system permease protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable). Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. | 0.999 |