node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acrA | acrR | b0463 | b0464 | Multidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. | Transcriptional repressor; Potential regulator protein for the acrAB genes. | 0.959 |
acrA | marA | b0463 | b1531 | Multidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | 0.899 |
acrA | marB | b0463 | b1532 | Multidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. | Periplasmic mar operon regulator; Multiple antibiotic resistance protein; Protein involved in response to drug and xenobiotic metabolic process. | 0.529 |
acrA | marR | b0463 | b1530 | Multidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. | Transcriptional repressor of multiple antibiotic resistance; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site. | 0.816 |
acrA | rob | b0463 | b4396 | Multidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. | Right oriC-binding transcriptional activator, AraC family; Binds to the right arm of the replication origin oriC of the chromosome. Rob binding may influence the formation of the nucleoprotein structure, required for oriC function in the initiation of replication. | 0.736 |
acrA | soxS | b0463 | b4062 | Multidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. | Superoxide response regulon transcriptional activator; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters. | 0.874 |
acrR | acrA | b0464 | b0463 | Transcriptional repressor; Potential regulator protein for the acrAB genes. | Multidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. | 0.959 |
acrR | marA | b0464 | b1531 | Transcriptional repressor; Potential regulator protein for the acrAB genes. | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | 0.920 |
acrR | marB | b0464 | b1532 | Transcriptional repressor; Potential regulator protein for the acrAB genes. | Periplasmic mar operon regulator; Multiple antibiotic resistance protein; Protein involved in response to drug and xenobiotic metabolic process. | 0.523 |
acrR | marR | b0464 | b1530 | Transcriptional repressor; Potential regulator protein for the acrAB genes. | Transcriptional repressor of multiple antibiotic resistance; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site. | 0.906 |
acrR | rob | b0464 | b4396 | Transcriptional repressor; Potential regulator protein for the acrAB genes. | Right oriC-binding transcriptional activator, AraC family; Binds to the right arm of the replication origin oriC of the chromosome. Rob binding may influence the formation of the nucleoprotein structure, required for oriC function in the initiation of replication. | 0.862 |
acrR | soxS | b0464 | b4062 | Transcriptional repressor; Potential regulator protein for the acrAB genes. | Superoxide response regulon transcriptional activator; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters. | 0.912 |
inaA | marA | b2237 | b1531 | Acid-inducible Kdo/WaaP family putative kinase; May be an environmental sensor responsive to several stimuli, including internal pH, proton motive force, temperature, and possibly other unknown factors; Belongs to the protein kinase superfamily. KdkA/RfaP family. | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | 0.767 |
inaA | marB | b2237 | b1532 | Acid-inducible Kdo/WaaP family putative kinase; May be an environmental sensor responsive to several stimuli, including internal pH, proton motive force, temperature, and possibly other unknown factors; Belongs to the protein kinase superfamily. KdkA/RfaP family. | Periplasmic mar operon regulator; Multiple antibiotic resistance protein; Protein involved in response to drug and xenobiotic metabolic process. | 0.520 |
inaA | marR | b2237 | b1530 | Acid-inducible Kdo/WaaP family putative kinase; May be an environmental sensor responsive to several stimuli, including internal pH, proton motive force, temperature, and possibly other unknown factors; Belongs to the protein kinase superfamily. KdkA/RfaP family. | Transcriptional repressor of multiple antibiotic resistance; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site. | 0.674 |
inaA | rob | b2237 | b4396 | Acid-inducible Kdo/WaaP family putative kinase; May be an environmental sensor responsive to several stimuli, including internal pH, proton motive force, temperature, and possibly other unknown factors; Belongs to the protein kinase superfamily. KdkA/RfaP family. | Right oriC-binding transcriptional activator, AraC family; Binds to the right arm of the replication origin oriC of the chromosome. Rob binding may influence the formation of the nucleoprotein structure, required for oriC function in the initiation of replication. | 0.541 |
inaA | soxS | b2237 | b4062 | Acid-inducible Kdo/WaaP family putative kinase; May be an environmental sensor responsive to several stimuli, including internal pH, proton motive force, temperature, and possibly other unknown factors; Belongs to the protein kinase superfamily. KdkA/RfaP family. | Superoxide response regulon transcriptional activator; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters. | 0.738 |
marA | acrA | b1531 | b0463 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Multidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. | 0.899 |
marA | acrR | b1531 | b0464 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Transcriptional repressor; Potential regulator protein for the acrAB genes. | 0.920 |
marA | inaA | b1531 | b2237 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Acid-inducible Kdo/WaaP family putative kinase; May be an environmental sensor responsive to several stimuli, including internal pH, proton motive force, temperature, and possibly other unknown factors; Belongs to the protein kinase superfamily. KdkA/RfaP family. | 0.767 |