STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ydfIPutative oxidoreductase; Belongs to the mannitol dehydrogenase family. UxuB subfamily. (486 aa)    
Predicted Functional Partners:
mtlA
Mannitol-specific PTS enzyme: IIA, IIB and IIC components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in D-mannitol transport. Also able to use D-mannonic acid.
  
  
 0.922
uxuA
Mannonate hydrolase; Catalyzes the dehydration of D-mannonate.
   
 0.640
cmtA
Putative mannitol-specific PTS IIB and IIC components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.
  
  
 0.591
kdgK
2-dehydro-3-deoxygluconokinase; Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). Belongs to the carbohydrate kinase PfkB family.
 
   
 0.569
fruB
Fused fructose-specific PTS enzymes: IIA component/HPr component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport.
  
  
 0.541
uxaA
Altronate hydrolase; Catalyzes the dehydration of D-altronate.
   
 0.506
rspR
Transcriptional repressor for rspAB; Repressor of the rspAB operon. Acts by binding directly to the upstream region of rspA.
   
 0.452
rspA
Bifunctional D-altronate/D-mannonate dehydratase; Probably involved in the degradation of homoserine lactone (HSL) or of a metabolite of HSL that signals starvation.
 
  
 0.421
torS
Hybrid sensory histidine kinase in two-component regulatory system with TorR; Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Detects the presence of TMAO in the medium and, in response, activates TorR via a four-step phosphorelay. When TMAO is removed, TorS can dephosphorylate TorR, probably by a reverse phosphorelay involving His- 860 and Asp-733.
   
  
 0.402
torT
Periplasmic sensory protein associated with the TorRS two-component regulatory system; Upon binding a putative inducer it probably interacts with TorS and allows it to play a role in the induction of the torCAD operon for trimethylamine N-oxide reductase; Belongs to the bacterial solute-binding protein 2 family.
   
  
 0.402
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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