node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hdeD | kefB | b3511 | b3350 | Acid-resistance membrane protein. | Potassium:proton antiporter; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily. | 0.475 |
hdeD | lhr | b3511 | b1653 | Acid-resistance membrane protein. | Member of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family. | 0.472 |
hdeD | yfdX | b3511 | b2375 | Acid-resistance membrane protein. | Uncharacterized protein. | 0.478 |
helD | lhr | b0962 | b1653 | DNA helicase IV; Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP. | Member of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family. | 0.453 |
helD | radA | b0962 | b4389 | DNA helicase IV; Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP. | DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. Genetic experiments involving combination of radA mutations with mutations in recA, recB, recG, [...] | 0.420 |
helD | yoaA | b0962 | b1808 | DNA helicase IV; Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP. | Putative ATP-dependent helicase, DinG family; DNA-dependent ATPase and 5'-3' DNA helicase (By similarity). Involved in the repair of replication forks and tolerance of the chain- terminating nucleoside analog 3' azidothymidine (AZT). May unwind potentially damaged 3' nascent ends such as those terminated by AZT, promote repair and AZT excision. | 0.570 |
idi | lhr | b2889 | b1653 | Isopentenyl diphosphate isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | Member of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family. | 0.452 |
kefB | hdeD | b3350 | b3511 | Potassium:proton antiporter; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily. | Acid-resistance membrane protein. | 0.475 |
kefB | lhr | b3350 | b1653 | Potassium:proton antiporter; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily. | Member of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family. | 0.603 |
kefB | yfdX | b3350 | b2375 | Potassium:proton antiporter; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily. | Uncharacterized protein. | 0.624 |
lhr | hdeD | b1653 | b3511 | Member of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family. | Acid-resistance membrane protein. | 0.472 |
lhr | helD | b1653 | b0962 | Member of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family. | DNA helicase IV; Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP. | 0.453 |
lhr | idi | b1653 | b2889 | Member of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family. | Isopentenyl diphosphate isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | 0.452 |
lhr | kefB | b1653 | b3350 | Member of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family. | Potassium:proton antiporter; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily. | 0.603 |
lhr | mutM | b1653 | b3635 | Member of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family. | Formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG) and its derivatives such as guanidinohydantoin:C and spiroiminodihydantoin:C, however it also acts on thymine glycol:G, 5,6-dihydrouracil:G and 5-hydroxyuracil:G. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-de [...] | 0.511 |
lhr | nei | b1653 | b0714 | Member of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family. | Endonuclease VIII and 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Acts on DNA bubble and 3'-fork structures, suggesting a role in replication- associated DNA repair. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a sing [...] | 0.511 |
lhr | radA | b1653 | b4389 | Member of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family. | DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. Genetic experiments involving combination of radA mutations with mutations in recA, recB, recG, [...] | 0.598 |
lhr | rnt | b1653 | b1652 | Member of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family. | RNase T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis, especially in strains lacking other exoribonucleases. | 0.763 |
lhr | yfdX | b1653 | b2375 | Member of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family. | Uncharacterized protein. | 0.595 |
lhr | yoaA | b1653 | b1808 | Member of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family. | Putative ATP-dependent helicase, DinG family; DNA-dependent ATPase and 5'-3' DNA helicase (By similarity). Involved in the repair of replication forks and tolerance of the chain- terminating nucleoside analog 3' azidothymidine (AZT). May unwind potentially damaged 3' nascent ends such as those terminated by AZT, promote repair and AZT excision. | 0.520 |