node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ghxP | purR | b4064 | b1658 | Guanine/hypoxanthine permease, high affinity; High-affinity transporter for guanine and hypoxanthine. | Transcriptional repressor, hypoxanthine-binding; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. In addition, it participates in the regulation or coregulation of genes involved in de novo pyrimidine nucleotide biosynthesis, salvage and uptake (pyrC, pyrD, carAB and codBA), and of several genes encoding enzymes necessary for nucleotide and polyamine biosynthesis (prsA, glyA, gcvTHP, speA, glnB). Binds to a 16-bp palindromic sequence located within the promoter region [...] | 0.504 |
ghxP | ydhC | b4064 | b1660 | Guanine/hypoxanthine permease, high affinity; High-affinity transporter for guanine and hypoxanthine. | Putative arabinose efflux transporter; Putative transport protein. | 0.524 |
hsrA | ydhC | b3754 | b1660 | Putative multidrug or homocysteine efflux system; Putative transport protein (MFS family); high copy suppressor of RspA: relieves RspA-mediated reduction of sigma(S) levels; overexpression also reduces MetE activity; effect proposed to be via an elevation in levels of homocysteine, causing a concomitant increase in homocysteine thiolactone; overexpression has no effect on resistance to a variety of toxic compounds; overexpression has no effect on resistance to a variety of toxic compounds; Belongs to the major facilitator superfamily. EmrB family. | Putative arabinose efflux transporter; Putative transport protein. | 0.487 |
iceT | ydhC | b2077 | b1660 | Putative citrate/iron-citrate/zinc-citrate efflux transporter; Putative transport protein; Belongs to the major facilitator superfamily. TCR/Tet family. | Putative arabinose efflux transporter; Putative transport protein. | 0.504 |
iceT | yfcJ | b2077 | b2322 | Putative citrate/iron-citrate/zinc-citrate efflux transporter; Putative transport protein; Belongs to the major facilitator superfamily. TCR/Tet family. | Putative arabinose efflux transporter; Overexpression has no effect on intracellular arabinose concentrations. | 0.478 |
mhpT | ydhC | b0353 | b1660 | 3-hydroxyphenylpropionic transporter; Uptake of 3-(3-hydroxyphenyl)propionate (3HPP) across the cytoplasmic membrane. Transport is driven by the proton motive force. Does not transport benzoate, 3-hydroxybenzoate or gentisate. Belongs to the major facilitator superfamily. Aromatic acid:H(+) symporter (AAHS) (TC 2.A.1.15) family. | Putative arabinose efflux transporter; Putative transport protein. | 0.547 |
mhpT | yfcJ | b0353 | b2322 | 3-hydroxyphenylpropionic transporter; Uptake of 3-(3-hydroxyphenyl)propionate (3HPP) across the cytoplasmic membrane. Transport is driven by the proton motive force. Does not transport benzoate, 3-hydroxybenzoate or gentisate. Belongs to the major facilitator superfamily. Aromatic acid:H(+) symporter (AAHS) (TC 2.A.1.15) family. | Putative arabinose efflux transporter; Overexpression has no effect on intracellular arabinose concentrations. | 0.806 |
mhpT | yhhS | b0353 | b3473 | 3-hydroxyphenylpropionic transporter; Uptake of 3-(3-hydroxyphenyl)propionate (3HPP) across the cytoplasmic membrane. Transport is driven by the proton motive force. Does not transport benzoate, 3-hydroxybenzoate or gentisate. Belongs to the major facilitator superfamily. Aromatic acid:H(+) symporter (AAHS) (TC 2.A.1.15) family. | Putative arabinose efflux transporter; Confers high-level resistance to glyphosate when overexpressed. Overexpression has no effect on intracellular arabinose concentrations. Belongs to the major facilitator superfamily. YhhS family. | 0.624 |
purR | ghxP | b1658 | b4064 | Transcriptional repressor, hypoxanthine-binding; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. In addition, it participates in the regulation or coregulation of genes involved in de novo pyrimidine nucleotide biosynthesis, salvage and uptake (pyrC, pyrD, carAB and codBA), and of several genes encoding enzymes necessary for nucleotide and polyamine biosynthesis (prsA, glyA, gcvTHP, speA, glnB). Binds to a 16-bp palindromic sequence located within the promoter region [...] | Guanine/hypoxanthine permease, high affinity; High-affinity transporter for guanine and hypoxanthine. | 0.504 |
purR | ydhC | b1658 | b1660 | Transcriptional repressor, hypoxanthine-binding; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. In addition, it participates in the regulation or coregulation of genes involved in de novo pyrimidine nucleotide biosynthesis, salvage and uptake (pyrC, pyrD, carAB and codBA), and of several genes encoding enzymes necessary for nucleotide and polyamine biosynthesis (prsA, glyA, gcvTHP, speA, glnB). Binds to a 16-bp palindromic sequence located within the promoter region [...] | Putative arabinose efflux transporter; Putative transport protein. | 0.502 |
ydeA | ydhC | b1528 | b1660 | Arabinose efflux transporter, arabinose-inducible; Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites. Transports L-arabinose and to a lesser extent IPTG. Seems to contribute to the control of the arabinose regulon; Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family. | Putative arabinose efflux transporter; Putative transport protein. | 0.584 |
ydeA | yfcJ | b1528 | b2322 | Arabinose efflux transporter, arabinose-inducible; Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites. Transports L-arabinose and to a lesser extent IPTG. Seems to contribute to the control of the arabinose regulon; Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family. | Putative arabinose efflux transporter; Overexpression has no effect on intracellular arabinose concentrations. | 0.530 |
ydhB | ydhC | b1659 | b1660 | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. | Putative arabinose efflux transporter; Putative transport protein. | 0.930 |
ydhC | ghxP | b1660 | b4064 | Putative arabinose efflux transporter; Putative transport protein. | Guanine/hypoxanthine permease, high affinity; High-affinity transporter for guanine and hypoxanthine. | 0.524 |
ydhC | hsrA | b1660 | b3754 | Putative arabinose efflux transporter; Putative transport protein. | Putative multidrug or homocysteine efflux system; Putative transport protein (MFS family); high copy suppressor of RspA: relieves RspA-mediated reduction of sigma(S) levels; overexpression also reduces MetE activity; effect proposed to be via an elevation in levels of homocysteine, causing a concomitant increase in homocysteine thiolactone; overexpression has no effect on resistance to a variety of toxic compounds; overexpression has no effect on resistance to a variety of toxic compounds; Belongs to the major facilitator superfamily. EmrB family. | 0.487 |
ydhC | iceT | b1660 | b2077 | Putative arabinose efflux transporter; Putative transport protein. | Putative citrate/iron-citrate/zinc-citrate efflux transporter; Putative transport protein; Belongs to the major facilitator superfamily. TCR/Tet family. | 0.504 |
ydhC | mhpT | b1660 | b0353 | Putative arabinose efflux transporter; Putative transport protein. | 3-hydroxyphenylpropionic transporter; Uptake of 3-(3-hydroxyphenyl)propionate (3HPP) across the cytoplasmic membrane. Transport is driven by the proton motive force. Does not transport benzoate, 3-hydroxybenzoate or gentisate. Belongs to the major facilitator superfamily. Aromatic acid:H(+) symporter (AAHS) (TC 2.A.1.15) family. | 0.547 |
ydhC | purR | b1660 | b1658 | Putative arabinose efflux transporter; Putative transport protein. | Transcriptional repressor, hypoxanthine-binding; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. In addition, it participates in the regulation or coregulation of genes involved in de novo pyrimidine nucleotide biosynthesis, salvage and uptake (pyrC, pyrD, carAB and codBA), and of several genes encoding enzymes necessary for nucleotide and polyamine biosynthesis (prsA, glyA, gcvTHP, speA, glnB). Binds to a 16-bp palindromic sequence located within the promoter region [...] | 0.502 |
ydhC | ydeA | b1660 | b1528 | Putative arabinose efflux transporter; Putative transport protein. | Arabinose efflux transporter, arabinose-inducible; Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites. Transports L-arabinose and to a lesser extent IPTG. Seems to contribute to the control of the arabinose regulon; Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family. | 0.584 |
ydhC | ydhB | b1660 | b1659 | Putative arabinose efflux transporter; Putative transport protein. | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. | 0.930 |