node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aroD | ydiB | b1693 | b1692 | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids (AroAA). Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of a lys-170 at the active site. | Quinate/shikimate 5-dehydrogenase, NAD(P)-binding; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. | 0.998 |
aroD | ydiL | b1693 | b1689 | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids (AroAA). Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of a lys-170 at the active site. | Putative HTH domain DNA-binding protein. | 0.401 |
aroD | ydiM | b1693 | b1690 | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids (AroAA). Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of a lys-170 at the active site. | Putative MFS transporter, membrane protein; Putative transport system permease protein. | 0.866 |
aroD | ydiN | b1693 | b1691 | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids (AroAA). Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of a lys-170 at the active site. | Putative MFS transporter, membrane protein; Putative amino acid/amine transport protein. | 0.956 |
psuK | ydiM | b2166 | b1690 | Pseudouridine kinase; Catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP). | Putative MFS transporter, membrane protein; Putative transport system permease protein. | 0.535 |
psuK | ydiP | b2166 | b1696 | Pseudouridine kinase; Catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP). | Putative ARAC-type regulatory protein; Protein involved in transcription and regulation of transcription, DNA-dependent. | 0.519 |
ydiB | aroD | b1692 | b1693 | Quinate/shikimate 5-dehydrogenase, NAD(P)-binding; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids (AroAA). Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of a lys-170 at the active site. | 0.998 |
ydiB | ydiL | b1692 | b1689 | Quinate/shikimate 5-dehydrogenase, NAD(P)-binding; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. | Putative HTH domain DNA-binding protein. | 0.517 |
ydiB | ydiM | b1692 | b1690 | Quinate/shikimate 5-dehydrogenase, NAD(P)-binding; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. | Putative MFS transporter, membrane protein; Putative transport system permease protein. | 0.896 |
ydiB | ydiN | b1692 | b1691 | Quinate/shikimate 5-dehydrogenase, NAD(P)-binding; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. | Putative MFS transporter, membrane protein; Putative amino acid/amine transport protein. | 0.988 |
ydiL | aroD | b1689 | b1693 | Putative HTH domain DNA-binding protein. | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids (AroAA). Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of a lys-170 at the active site. | 0.401 |
ydiL | ydiB | b1689 | b1692 | Putative HTH domain DNA-binding protein. | Quinate/shikimate 5-dehydrogenase, NAD(P)-binding; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. | 0.517 |
ydiL | ydiM | b1689 | b1690 | Putative HTH domain DNA-binding protein. | Putative MFS transporter, membrane protein; Putative transport system permease protein. | 0.820 |
ydiL | ydiN | b1689 | b1691 | Putative HTH domain DNA-binding protein. | Putative MFS transporter, membrane protein; Putative amino acid/amine transport protein. | 0.820 |
ydiM | aroD | b1690 | b1693 | Putative MFS transporter, membrane protein; Putative transport system permease protein. | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids (AroAA). Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of a lys-170 at the active site. | 0.866 |
ydiM | psuK | b1690 | b2166 | Putative MFS transporter, membrane protein; Putative transport system permease protein. | Pseudouridine kinase; Catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP). | 0.535 |
ydiM | ydiB | b1690 | b1692 | Putative MFS transporter, membrane protein; Putative transport system permease protein. | Quinate/shikimate 5-dehydrogenase, NAD(P)-binding; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. | 0.896 |
ydiM | ydiL | b1690 | b1689 | Putative MFS transporter, membrane protein; Putative transport system permease protein. | Putative HTH domain DNA-binding protein. | 0.820 |
ydiM | ydiN | b1690 | b1691 | Putative MFS transporter, membrane protein; Putative transport system permease protein. | Putative MFS transporter, membrane protein; Putative amino acid/amine transport protein. | 0.674 |
ydiM | ydiP | b1690 | b1696 | Putative MFS transporter, membrane protein; Putative transport system permease protein. | Putative ARAC-type regulatory protein; Protein involved in transcription and regulation of transcription, DNA-dependent. | 0.693 |