STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dmlAD-malate oxidase, NAD-dependent; Catalyzes the NAD(+)-dependent oxidative decarboxylation of D-malate into pyruvate. Is essential for aerobic growth on D-malate as the sole carbon source. But is not required for anaerobic D-malate utilization, although DmlA is expressed and active in those conditions. Appears to be not able to use L-tartrate as a substrate for dehydrogenation instead of D-malate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (361 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase III, valine sensitive, small subunit.
 
 0.968
ilvN
Acetolactate synthase I, valine sensitive, small subunit.
  
 0.958
ilvI
Acetolactate synthase III, valine sensitive, large subunit.
 
 0.953
ilvB
Acetolactate synthase I,valine-sensitive, large subunit.
 
 0.952
pflD
Putative glycine radical domain-containing pyruvate formate-lyase; Probably shows dehydratase activity. Belongs to the glycyl radical enzyme (GRE) family.
     
 0.949
ttdB
L-tartrate dehydratase, subunit B; Protein involved in fermentation.
 
 
 0.947
pfo
Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin.
  
 
 0.934
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
 
 0.927
ybiW
Putative pyruvate formate lyase; Probably shows dehydratase activity. Belongs to the glycyl radical enzyme (GRE) family.
     
 0.924
ttdA
L-tartrate dehydratase, subunit A; Protein involved in fermentation.
 
  
 0.923
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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