node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
alx | mntP | b3088 | b1821 | Putative membrane-bound redox modulator; Has been proposed to be a redox modulator. | Putative Mn(2+) efflux pump, mntR-regulated; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family. | 0.631 |
fieF | iceT | b3915 | b2077 | Ferrous iron and zinc transporter; Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily. | Putative citrate/iron-citrate/zinc-citrate efflux transporter; Putative transport protein; Belongs to the major facilitator superfamily. TCR/Tet family. | 0.735 |
fieF | mntH | b3915 | b2392 | Ferrous iron and zinc transporter; Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily. | Manganese/divalent cation transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen. | 0.677 |
fieF | mntP | b3915 | b1821 | Ferrous iron and zinc transporter; Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily. | Putative Mn(2+) efflux pump, mntR-regulated; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family. | 0.584 |
fieF | mntR | b3915 | b0817 | Ferrous iron and zinc transporter; Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily. | Mn(2+)-responsive manganese regulon transcriptional regulator; In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP. | 0.675 |
fieF | mntS | b3915 | b4705 | Ferrous iron and zinc transporter; Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily. | Mn(2)-response protein, MntR-repressed; Required for repression of mntH by MntR. May function as a chaperone that makes manganese more available by delivering it to the necessary cellular locations when manganese is limiting. | 0.400 |
fieF | zitB | b3915 | b0752 | Ferrous iron and zinc transporter; Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily. | Zinc efflux system; Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc, whereas ZntA is required for growth at more toxic concentrations; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. | 0.689 |
fieF | zntA | b3915 | b3469 | Ferrous iron and zinc transporter; Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily. | Zinc, cobalt and lead efflux system; Confers resistance to zinc, cadmium and lead. Couples the hydrolysis of ATP with the export of zinc, cadmium or lead, with highest activity when the metals are present as metal-thiolate complexes. Can also bind nickel, copper, cobalt and mercury. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | 0.937 |
iceT | fieF | b2077 | b3915 | Putative citrate/iron-citrate/zinc-citrate efflux transporter; Putative transport protein; Belongs to the major facilitator superfamily. TCR/Tet family. | Ferrous iron and zinc transporter; Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily. | 0.735 |
iceT | mntP | b2077 | b1821 | Putative citrate/iron-citrate/zinc-citrate efflux transporter; Putative transport protein; Belongs to the major facilitator superfamily. TCR/Tet family. | Putative Mn(2+) efflux pump, mntR-regulated; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family. | 0.526 |
iceT | zitB | b2077 | b0752 | Putative citrate/iron-citrate/zinc-citrate efflux transporter; Putative transport protein; Belongs to the major facilitator superfamily. TCR/Tet family. | Zinc efflux system; Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc, whereas ZntA is required for growth at more toxic concentrations; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. | 0.523 |
iceT | zntA | b2077 | b3469 | Putative citrate/iron-citrate/zinc-citrate efflux transporter; Putative transport protein; Belongs to the major facilitator superfamily. TCR/Tet family. | Zinc, cobalt and lead efflux system; Confers resistance to zinc, cadmium and lead. Couples the hydrolysis of ATP with the export of zinc, cadmium or lead, with highest activity when the metals are present as metal-thiolate complexes. Can also bind nickel, copper, cobalt and mercury. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | 0.490 |
mgtA | mntH | b4242 | b2392 | Magnesium transporter; Mediates magnesium influx to the cytosol. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily. | Manganese/divalent cation transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen. | 0.701 |
mgtA | mntP | b4242 | b1821 | Magnesium transporter; Mediates magnesium influx to the cytosol. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily. | Putative Mn(2+) efflux pump, mntR-regulated; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family. | 0.410 |
mntH | fieF | b2392 | b3915 | Manganese/divalent cation transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen. | Ferrous iron and zinc transporter; Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily. | 0.677 |
mntH | mgtA | b2392 | b4242 | Manganese/divalent cation transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen. | Magnesium transporter; Mediates magnesium influx to the cytosol. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily. | 0.701 |
mntH | mntP | b2392 | b1821 | Manganese/divalent cation transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen. | Putative Mn(2+) efflux pump, mntR-regulated; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family. | 0.910 |
mntH | mntR | b2392 | b0817 | Manganese/divalent cation transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen. | Mn(2+)-responsive manganese regulon transcriptional regulator; In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP. | 0.951 |
mntH | mntS | b2392 | b4705 | Manganese/divalent cation transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen. | Mn(2)-response protein, MntR-repressed; Required for repression of mntH by MntR. May function as a chaperone that makes manganese more available by delivering it to the necessary cellular locations when manganese is limiting. | 0.622 |
mntH | zitB | b2392 | b0752 | Manganese/divalent cation transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen. | Zinc efflux system; Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc, whereas ZntA is required for growth at more toxic concentrations; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. | 0.534 |