STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
wcaJColanic biosynthesis UDP-glucose lipid carrier transferase; Is the initiating enzyme for colanic acid (CA) synthesis. Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P), forming a phosphoanhydride bond yielding to glucosyl-pyrophosphoryl-undecaprenol (Glc-PP-C55). Also possesses a weak galactose-1-P transferase activity. Belongs to the bacterial sugar transferase family. (464 aa)    
Predicted Functional Partners:
wzc
Colanic acid production tyrosine-protein kinase; Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg.
 
  
 0.998
wzxC
Putative colanic acid exporter; Probable export protein; Belongs to the polysaccharide synthase family.
 
  
 0.995
wcaI
Putative colanic biosynthesis glycosyl transferase; Protein involved in colanic acid biosynthetic process.
 
 0.993
cpsB
Mannose-1-phosphate guanyltransferase; Involved in the biosynthesis of the capsular polysaccharide colanic acid.
 
  
 0.992
wza
Colanic acid export protein; Probably involved in the export of the extracellular polysaccharide colanic acid from the cell to medium.
 
  
 0.990
wcaG
GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
  
  
 0.981
wcaA
Putative glycosyl transferase; Putative regulator; Protein involved in colanic acid biosynthetic process.
 
  
 0.981
gmd
GDP-D-mannose dehydratase, NAD(P)-binding; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
  
  
 0.977
wcaC
Putative glycosyl transferase; Protein involved in colanic acid biosynthetic process.
 
  
 0.969
etk
Tyrosine-protein kinase, role in O-antigen capsule formation; Protein involved in protein modification process; Belongs to the etk/wzc family.
 
  
 0.961
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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