STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccmEPeriplasmic heme chaperone; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH; Belongs to the CcmE/CycJ family. (159 aa)    
Predicted Functional Partners:
ccmF
Heme lyase, CcmF subunit; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.
 
 
 0.999
ccmD
Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
 
 0.999
ccmC
Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
 0.999
ccmB
Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
 
 0.999
dsbE
Periplasmic thioredoxin of cytochrome c-type biogenesis; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase. DsbE is maintained in a reduced state by DsbD.
 
  
 0.998
ccmA
Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
 
 0.998
ccmH
Heme lyase, CcmH subunit; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.
 
  
 0.995
napC
Quinol dehydrogenase, electron source for NapAB; Mediates electron flow from quinones to the NapAB complex.
 
  
 0.881
nrfF
Heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfF; Not required for the biosynthesis of any of the c-type cytochromes. Possible subunit of a heme lyase.
 
  
 0.868
nrfE
Heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfE; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.
 
  
 0.865
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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