node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ada | alkB | b2213 | b2212 | Fused DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs O6-methylguanine (O6-MeG) and O4- methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme (Cys-321). Also specifically repairs the Sp diastereomer of DNA methylphosphotriester lesions by the same mechanism, although the methyl transfer occurs onto a different cysteine residue (Cys-38). Cannot demeth [...] | Oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions; Dioxygenase that repairs alkylated DNA and RNA containing 3- methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha- ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not t [...] | 0.977 |
ada | yojI | b2213 | b2211 | Fused DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs O6-methylguanine (O6-MeG) and O4- methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme (Cys-321). Also specifically repairs the Sp diastereomer of DNA methylphosphotriester lesions by the same mechanism, although the methyl transfer occurs onto a different cysteine residue (Cys-38). Cannot demeth [...] | Microcin J25 efflux ABC transporter permease/ATPase; Mediates resistance to the antibacterial peptide microcin J25, when expressed from a multicopy vector. Functions as an efflux pump for microcin J25, with the help of the outer membrane channel TolC. | 0.841 |
alkB | ada | b2212 | b2213 | Oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions; Dioxygenase that repairs alkylated DNA and RNA containing 3- methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha- ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not t [...] | Fused DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs O6-methylguanine (O6-MeG) and O4- methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme (Cys-321). Also specifically repairs the Sp diastereomer of DNA methylphosphotriester lesions by the same mechanism, although the methyl transfer occurs onto a different cysteine residue (Cys-38). Cannot demeth [...] | 0.977 |
alkB | yojI | b2212 | b2211 | Oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions; Dioxygenase that repairs alkylated DNA and RNA containing 3- methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha- ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not t [...] | Microcin J25 efflux ABC transporter permease/ATPase; Mediates resistance to the antibacterial peptide microcin J25, when expressed from a multicopy vector. Functions as an efflux pump for microcin J25, with the help of the outer membrane channel TolC. | 0.870 |
araF | fepB | b1901 | b0592 | L-arabinose ABC transporter periplasmic binding protein; Involved in the high-affinity L-arabinose membrane transport system. Binds with high affinity to arabinose, but can also bind D- galactose (approximately 2-fold reduction) and D-fucose (approximately 40-fold reduction). | Ferrienterobactin ABC transporter periplasmic binding protein; Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin. | 0.540 |
araF | fepC | b1901 | b0588 | L-arabinose ABC transporter periplasmic binding protein; Involved in the high-affinity L-arabinose membrane transport system. Binds with high affinity to arabinose, but can also bind D- galactose (approximately 2-fold reduction) and D-fucose (approximately 40-fold reduction). | Ferrienterobactin ABC transporter ATPase; Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system. | 0.540 |
araF | fhuB | b1901 | b0153 | L-arabinose ABC transporter periplasmic binding protein; Involved in the high-affinity L-arabinose membrane transport system. Binds with high affinity to arabinose, but can also bind D- galactose (approximately 2-fold reduction) and D-fucose (approximately 40-fold reduction). | Iron(3+)-hydroxamate import ABC transporter permease; Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane. | 0.540 |
araF | fhuC | b1901 | b0151 | L-arabinose ABC transporter periplasmic binding protein; Involved in the high-affinity L-arabinose membrane transport system. Binds with high affinity to arabinose, but can also bind D- galactose (approximately 2-fold reduction) and D-fucose (approximately 40-fold reduction). | Iron(3+)-hydroxamate import ABC transporter ATPase; Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system. | 0.540 |
araF | fhuD | b1901 | b0152 | L-arabinose ABC transporter periplasmic binding protein; Involved in the high-affinity L-arabinose membrane transport system. Binds with high affinity to arabinose, but can also bind D- galactose (approximately 2-fold reduction) and D-fucose (approximately 40-fold reduction). | Iron(3+)-hydroxamate import ABC transporter periplasmic binding protein; Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin. | 0.540 |
araF | yojI | b1901 | b2211 | L-arabinose ABC transporter periplasmic binding protein; Involved in the high-affinity L-arabinose membrane transport system. Binds with high affinity to arabinose, but can also bind D- galactose (approximately 2-fold reduction) and D-fucose (approximately 40-fold reduction). | Microcin J25 efflux ABC transporter permease/ATPase; Mediates resistance to the antibacterial peptide microcin J25, when expressed from a multicopy vector. Functions as an efflux pump for microcin J25, with the help of the outer membrane channel TolC. | 0.682 |
entF | fepB | b0586 | b0592 | Enterobactin synthase multienzyme complex component, ATP-dependent; Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE). | Ferrienterobactin ABC transporter periplasmic binding protein; Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin. | 0.981 |
entF | fepC | b0586 | b0588 | Enterobactin synthase multienzyme complex component, ATP-dependent; Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE). | Ferrienterobactin ABC transporter ATPase; Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system. | 0.892 |
entF | fhuD | b0586 | b0152 | Enterobactin synthase multienzyme complex component, ATP-dependent; Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE). | Iron(3+)-hydroxamate import ABC transporter periplasmic binding protein; Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin. | 0.535 |
entF | fhuF | b0586 | b4367 | Enterobactin synthase multienzyme complex component, ATP-dependent; Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE). | Ferric iron reductase involved in ferric hydroximate transport; Involved in the reduction of ferric iron in cytoplasmic ferrioxamine B. | 0.603 |
entF | yojI | b0586 | b2211 | Enterobactin synthase multienzyme complex component, ATP-dependent; Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE). | Microcin J25 efflux ABC transporter permease/ATPase; Mediates resistance to the antibacterial peptide microcin J25, when expressed from a multicopy vector. Functions as an efflux pump for microcin J25, with the help of the outer membrane channel TolC. | 0.694 |
fepB | araF | b0592 | b1901 | Ferrienterobactin ABC transporter periplasmic binding protein; Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin. | L-arabinose ABC transporter periplasmic binding protein; Involved in the high-affinity L-arabinose membrane transport system. Binds with high affinity to arabinose, but can also bind D- galactose (approximately 2-fold reduction) and D-fucose (approximately 40-fold reduction). | 0.540 |
fepB | entF | b0592 | b0586 | Ferrienterobactin ABC transporter periplasmic binding protein; Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin. | Enterobactin synthase multienzyme complex component, ATP-dependent; Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE). | 0.981 |
fepB | fepC | b0592 | b0588 | Ferrienterobactin ABC transporter periplasmic binding protein; Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin. | Ferrienterobactin ABC transporter ATPase; Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system. | 0.999 |
fepB | fhuB | b0592 | b0153 | Ferrienterobactin ABC transporter periplasmic binding protein; Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin. | Iron(3+)-hydroxamate import ABC transporter permease; Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane. | 0.817 |
fepB | fhuC | b0592 | b0151 | Ferrienterobactin ABC transporter periplasmic binding protein; Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin. | Iron(3+)-hydroxamate import ABC transporter ATPase; Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system. | 0.929 |