node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
rtcA | yfaP | b4475 | b2225 | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing; Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily. | DUF2135 family protein, putative host defense protein. | 0.493 |
rtcA | ynbD | b4475 | b1411 | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing; Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily. | Putative phosphatase inner membrane protein; Putative enzymes; Belongs to the protein-tyrosine phosphatase family. | 0.603 |
ycbF | yfaP | b0944 | b2225 | Putative periplasmic pilin chaperone; Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of fimbriae; Belongs to the periplasmic pilus chaperone family. | DUF2135 family protein, putative host defense protein. | 0.545 |
yebE | yfaP | b1846 | b2225 | DUF533 family inner membrane protein. | DUF2135 family protein, putative host defense protein. | 0.504 |
yebZ | yfaP | b1840 | b2225 | Inner membrane protein; Putative resistance protein; Protein involved in response to drug. | DUF2135 family protein, putative host defense protein. | 0.642 |
yfaA | yfaP | b2230 | b2225 | DUF2138 family protein, putative host defense protein. | DUF2135 family protein, putative host defense protein. | 0.956 |
yfaA | yfaQ | b2230 | b2226 | DUF2138 family protein, putative host defense protein. | Tandem DUF2300 domain protein, putative host defense protein. | 0.935 |
yfaA | yfaT | b2230 | b2229 | DUF2138 family protein, putative host defense protein. | Uncharacterized protein YfaT; Pseudogene, bacterial alpha2-macroglobulin YfaS variant family; putative membrane protein; To P.aeruginosa PA4490 and T.maritima TM0986. | 0.986 |
yfaA | yfhM | b2230 | b2520 | DUF2138 family protein, putative host defense protein. | Bacterial alpha2-macroglobulin colonization factor ECAM; Protects the bacterial cell from host peptidases. Acts by a 'trapping' mechanism. Cleavage of the bait-region domain by host peptidases leads to a global conformational change, which results in entrapment of the host peptidase and activation of the thioester bond that covalently binds the attacking host peptidase. Trapped peptidases are still active except against very large substrates. May protect the entire periplam, including the lipoproteins anchored to the periplasmic side of the outer membrane, against intruding endopeptidases. | 0.695 |
yfaP | rtcA | b2225 | b4475 | DUF2135 family protein, putative host defense protein. | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing; Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily. | 0.493 |
yfaP | ycbF | b2225 | b0944 | DUF2135 family protein, putative host defense protein. | Putative periplasmic pilin chaperone; Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of fimbriae; Belongs to the periplasmic pilus chaperone family. | 0.545 |
yfaP | yebE | b2225 | b1846 | DUF2135 family protein, putative host defense protein. | DUF533 family inner membrane protein. | 0.504 |
yfaP | yebZ | b2225 | b1840 | DUF2135 family protein, putative host defense protein. | Inner membrane protein; Putative resistance protein; Protein involved in response to drug. | 0.642 |
yfaP | yfaA | b2225 | b2230 | DUF2135 family protein, putative host defense protein. | DUF2138 family protein, putative host defense protein. | 0.956 |
yfaP | yfaQ | b2225 | b2226 | DUF2135 family protein, putative host defense protein. | Tandem DUF2300 domain protein, putative host defense protein. | 0.987 |
yfaP | yfaT | b2225 | b2229 | DUF2135 family protein, putative host defense protein. | Uncharacterized protein YfaT; Pseudogene, bacterial alpha2-macroglobulin YfaS variant family; putative membrane protein; To P.aeruginosa PA4490 and T.maritima TM0986. | 0.882 |
yfaP | yfhM | b2225 | b2520 | DUF2135 family protein, putative host defense protein. | Bacterial alpha2-macroglobulin colonization factor ECAM; Protects the bacterial cell from host peptidases. Acts by a 'trapping' mechanism. Cleavage of the bait-region domain by host peptidases leads to a global conformational change, which results in entrapment of the host peptidase and activation of the thioester bond that covalently binds the attacking host peptidase. Trapped peptidases are still active except against very large substrates. May protect the entire periplam, including the lipoproteins anchored to the periplasmic side of the outer membrane, against intruding endopeptidases. | 0.679 |
yfaP | yjbF | b2225 | b4027 | DUF2135 family protein, putative host defense protein. | Extracellular polysaccharide production lipoprotein. | 0.622 |
yfaP | ynbD | b2225 | b1411 | DUF2135 family protein, putative host defense protein. | Putative phosphatase inner membrane protein; Putative enzymes; Belongs to the protein-tyrosine phosphatase family. | 0.487 |
yfaQ | yfaA | b2226 | b2230 | Tandem DUF2300 domain protein, putative host defense protein. | DUF2138 family protein, putative host defense protein. | 0.935 |