STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yfaYInactive PncC family protein; Does not have nicotinamide-nucleotide (NMN) amidohydrolase activity. (400 aa)    
Predicted Functional Partners:
pncC
Nicotinamide-nucleotide amidohydrolase; Has nicotinamidemononucleotide (NMN) aminohydrolase activity, not active on other substrates; Belongs to the CinA family. PncC subfamily.
   
 0.944
ligT
2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, can also ligate 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. This reaction does not require ATP and is reversible. Belongs to the 2H phosphoesterase superfamily. ThpR family.
     
 0.915
recA
DNA recombination and repair protein; Required for homologous recombination and the bypass of mutagenic DNA lesions by the SOS response. Catalyzes ATP-driven homologous pairing and strand exchange of DNA molecules necessary for DNA recombinational repair. Catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single- stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in resp [...]
  
  
 0.681
ydeJ
Inactive PncC family protein; Does not have nicotinamide-nucleotide (NMN) amidohydrolase activity.
   
 0.618
yfaZ
Outer membrane protein, putative porin.
       0.585
recX
Regulatory protein for RecA; Modulates RecA activity through direct physical interaction. Can inhibit both RecA recombinase and coprotease activities. May have a regulatory role during the SOS response. Inhibits DNA strand exchange in vitro; Belongs to the RecX family.
     
 0.513
pgsA
Phosphatidylglycerophosphate synthetase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
  
  
 0.437
rhmR
Putative DNA-binding transcriptional regulator for the rhm operon; Putative regulator; Protein involved in transcription and regulation of transcription, DNA-dependent.
       0.437
ynbA
Inner membrane protein.
  
  
 0.431
ynjF
CDP-alcohol phosphatidyltransferase family inner membrane protein; Putative cytochrome oxidase.
  
  
 0.431
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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