node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fabR | mutH | b3963 | b2831 | Transcriptional repressor of fabA and fabB; Binds the promoter region of at least fabA and fabB, but probably not yqfA. Represses the transcription of fabA and fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. | 0.656 |
fabR | proQ | b3963 | b1831 | Transcriptional repressor of fabA and fabB; Binds the promoter region of at least fabA and fabB, but probably not yqfA. Represses the transcription of fabA and fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | RNA chaperone, putative ProP translation regulator; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. | 0.536 |
fabR | rraB | b3963 | b4255 | Transcriptional repressor of fabA and fabB; Binds the promoter region of at least fabA and fabB, but probably not yqfA. Represses the transcription of fabA and fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | Protein inhibitor of RNase E; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome; Belongs to the RraB family. | 0.712 |
fabR | seqA | b3963 | b0687 | Transcriptional repressor of fabA and fabB; Binds the promoter region of at least fabA and fabB, but probably not yqfA. Represses the transcription of fabA and fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | Negative modulator of initiation of replication; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. Can also bind to hemimethylated GATC sequences outside of oriC region. Binds, with less affinity, to fully methylated GATC si [...] | 0.745 |
fabR | syd | b3963 | b2793 | Transcriptional repressor of fabA and fabB; Binds the promoter region of at least fabA and fabB, but probably not yqfA. Represses the transcription of fabA and fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | SecY-interacting protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function; Belongs to the Syd family. | 0.643 |
fabR | yejL | b3963 | b2187 | Transcriptional repressor of fabA and fabB; Binds the promoter region of at least fabA and fabB, but probably not yqfA. Represses the transcription of fabA and fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | UPF0352 family protein; Belongs to the UPF0352 family. | 0.715 |
fabR | yfbV | b3963 | b2295 | Transcriptional repressor of fabA and fabB; Binds the promoter region of at least fabA and fabB, but probably not yqfA. Represses the transcription of fabA and fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | UPF0208 family inner membrane protein. | 0.748 |
fabR | yheV | b3963 | b4551 | Transcriptional repressor of fabA and fabB; Binds the promoter region of at least fabA and fabB, but probably not yqfA. Represses the transcription of fabA and fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | DUF2387 family putative metal-binding protein. | 0.526 |
fabR | yihI | b3963 | b3866 | Transcriptional repressor of fabA and fabB; Binds the promoter region of at least fabA and fabB, but probably not yqfA. Represses the transcription of fabA and fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | Activator of Der GTPase; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function, negatively regulating cell growth, probably via ribosome assembly. Stimulates the GTPase activity of Der; a construct missing the first 45 residues is even more stimulatory. Does not stimulate 2 other GTPases (ObgE and Era). Overexpression inhibits cell growth; precursor 16S rRNA accumulates, the 23S rRNA is 6-7 bases longer than usual, and 50S ribosomal subunits are improperly assembled, leading to 45S subunits lacking proteins L9, L18 and L25. Overexpression of Der in the same cells sup [...] | 0.658 |
mutH | fabR | b2831 | b3963 | Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. | Transcriptional repressor of fabA and fabB; Binds the promoter region of at least fabA and fabB, but probably not yqfA. Represses the transcription of fabA and fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | 0.656 |
mutH | proQ | b2831 | b1831 | Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. | RNA chaperone, putative ProP translation regulator; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. | 0.759 |
mutH | rraB | b2831 | b4255 | Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. | Protein inhibitor of RNase E; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome; Belongs to the RraB family. | 0.759 |
mutH | seqA | b2831 | b0687 | Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. | Negative modulator of initiation of replication; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. Can also bind to hemimethylated GATC sequences outside of oriC region. Binds, with less affinity, to fully methylated GATC si [...] | 0.949 |
mutH | syd | b2831 | b2793 | Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. | SecY-interacting protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function; Belongs to the Syd family. | 0.731 |
mutH | uspE | b2831 | b1333 | Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. | Stress-induced protein; Required for resistance to DNA-damaging agents. | 0.401 |
mutH | yejL | b2831 | b2187 | Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. | UPF0352 family protein; Belongs to the UPF0352 family. | 0.780 |
mutH | yfbV | b2831 | b2295 | Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. | UPF0208 family inner membrane protein. | 0.756 |
mutH | yheV | b2831 | b4551 | Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. | DUF2387 family putative metal-binding protein. | 0.696 |
mutH | yihI | b2831 | b3866 | Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. | Activator of Der GTPase; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function, negatively regulating cell growth, probably via ribosome assembly. Stimulates the GTPase activity of Der; a construct missing the first 45 residues is even more stimulatory. Does not stimulate 2 other GTPases (ObgE and Era). Overexpression inhibits cell growth; precursor 16S rRNA accumulates, the 23S rRNA is 6-7 bases longer than usual, and 50S ribosomal subunits are improperly assembled, leading to 45S subunits lacking proteins L9, L18 and L25. Overexpression of Der in the same cells sup [...] | 0.754 |
proQ | fabR | b1831 | b3963 | RNA chaperone, putative ProP translation regulator; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. | Transcriptional repressor of fabA and fabB; Binds the promoter region of at least fabA and fabB, but probably not yqfA. Represses the transcription of fabA and fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. | 0.536 |