node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
folE | folK | b2153 | b0142 | GTP cyclohydrolase I; Protein involved in folic acid biosynthetic process; Belongs to the GTP cyclohydrolase I family. | 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase; Protein involved in folic acid biosynthetic process; Belongs to the HPPK family. | 0.999 |
folE | folM | b2153 | b1606 | GTP cyclohydrolase I; Protein involved in folic acid biosynthetic process; Belongs to the GTP cyclohydrolase I family. | Dihydromonapterin reductase, NADPH-dependent; Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate. | 0.457 |
folE | folP | b2153 | b3177 | GTP cyclohydrolase I; Protein involved in folic acid biosynthetic process; Belongs to the GTP cyclohydrolase I family. | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. Belongs to the DHPS family. | 0.991 |
folE | folX | b2153 | b2303 | GTP cyclohydrolase I; Protein involved in folic acid biosynthetic process; Belongs to the GTP cyclohydrolase I family. | D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase; Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis, a major pterin in E.coli. | 0.992 |
folE | nudB | b2153 | b1865 | GTP cyclohydrolase I; Protein involved in folic acid biosynthetic process; Belongs to the GTP cyclohydrolase I family. | Dihydroneopterin triphosphate pyrophosphatase; Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP. | 0.942 |
folE | phoA | b2153 | b0383 | GTP cyclohydrolase I; Protein involved in folic acid biosynthetic process; Belongs to the GTP cyclohydrolase I family. | Alkaline phosphatase; start codon corrected; Protein involved in phosphorus metabolic process; Belongs to the alkaline phosphatase family. | 0.901 |
folE | queD | b2153 | b2765 | GTP cyclohydrolase I; Protein involved in folic acid biosynthetic process; Belongs to the GTP cyclohydrolase I family. | 6-pyruvoyl tetrahydrobiopterin synthase (PTPS); Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP. | 0.998 |
folK | folE | b0142 | b2153 | 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase; Protein involved in folic acid biosynthetic process; Belongs to the HPPK family. | GTP cyclohydrolase I; Protein involved in folic acid biosynthetic process; Belongs to the GTP cyclohydrolase I family. | 0.999 |
folK | folM | b0142 | b1606 | 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase; Protein involved in folic acid biosynthetic process; Belongs to the HPPK family. | Dihydromonapterin reductase, NADPH-dependent; Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate. | 0.508 |
folK | folP | b0142 | b3177 | 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase; Protein involved in folic acid biosynthetic process; Belongs to the HPPK family. | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. Belongs to the DHPS family. | 0.999 |
folK | folX | b0142 | b2303 | 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase; Protein involved in folic acid biosynthetic process; Belongs to the HPPK family. | D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase; Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis, a major pterin in E.coli. | 0.905 |
folK | nudB | b0142 | b1865 | 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase; Protein involved in folic acid biosynthetic process; Belongs to the HPPK family. | Dihydroneopterin triphosphate pyrophosphatase; Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP. | 0.419 |
folK | queD | b0142 | b2765 | 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase; Protein involved in folic acid biosynthetic process; Belongs to the HPPK family. | 6-pyruvoyl tetrahydrobiopterin synthase (PTPS); Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP. | 0.548 |
folM | folE | b1606 | b2153 | Dihydromonapterin reductase, NADPH-dependent; Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate. | GTP cyclohydrolase I; Protein involved in folic acid biosynthetic process; Belongs to the GTP cyclohydrolase I family. | 0.457 |
folM | folK | b1606 | b0142 | Dihydromonapterin reductase, NADPH-dependent; Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate. | 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase; Protein involved in folic acid biosynthetic process; Belongs to the HPPK family. | 0.508 |
folM | folP | b1606 | b3177 | Dihydromonapterin reductase, NADPH-dependent; Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate. | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. Belongs to the DHPS family. | 0.896 |
folM | folX | b1606 | b2303 | Dihydromonapterin reductase, NADPH-dependent; Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate. | D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase; Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis, a major pterin in E.coli. | 0.824 |
folP | folE | b3177 | b2153 | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. Belongs to the DHPS family. | GTP cyclohydrolase I; Protein involved in folic acid biosynthetic process; Belongs to the GTP cyclohydrolase I family. | 0.991 |
folP | folK | b3177 | b0142 | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. Belongs to the DHPS family. | 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase; Protein involved in folic acid biosynthetic process; Belongs to the HPPK family. | 0.999 |
folP | folM | b3177 | b1606 | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. Belongs to the DHPS family. | Dihydromonapterin reductase, NADPH-dependent; Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate. | 0.896 |