node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aegA | nudK | b2468 | b2467 | Putative oxidoreductase, FeS binding subunit/NAD/FAD-binding subunit. | GDP-mannose pyrophosphatase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. Can also hydrolyze the pyrophosphate bond of other sugar nucleotides such as IDP-ribose, GDP-glucose, and to a lesser extent, ADP-ribose, ADP-glucose and UDP-glucose. Shows no activity toward Nudix substrates FAD, CDP-ethanolamine, CDP-choline, NAD(+), diadenosine pentaphosphate, GTP, UTP, ATP, or CTP. | 0.601 |
birA | fabD | b3973 | b1092 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | malonyl-CoA-[acyl-carrier-protein] transacylase; Belongs to the FabD family. | 0.690 |
birA | nnr | b3973 | b4167 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Bifunctional NAD(P)H-hydrate repair enzyme; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the N-terminal section; belongs to the NnrE/AIBP family. | 0.495 |
birA | nudK | b3973 | b2467 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | GDP-mannose pyrophosphatase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. Can also hydrolyze the pyrophosphate bond of other sugar nucleotides such as IDP-ribose, GDP-glucose, and to a lesser extent, ADP-ribose, ADP-glucose and UDP-glucose. Shows no activity toward Nudix substrates FAD, CDP-ethanolamine, CDP-choline, NAD(+), diadenosine pentaphosphate, GTP, UTP, ATP, or CTP. | 0.534 |
fabD | birA | b1092 | b3973 | malonyl-CoA-[acyl-carrier-protein] transacylase; Belongs to the FabD family. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.690 |
fabD | nudK | b1092 | b2467 | malonyl-CoA-[acyl-carrier-protein] transacylase; Belongs to the FabD family. | GDP-mannose pyrophosphatase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. Can also hydrolyze the pyrophosphate bond of other sugar nucleotides such as IDP-ribose, GDP-glucose, and to a lesser extent, ADP-ribose, ADP-glucose and UDP-glucose. Shows no activity toward Nudix substrates FAD, CDP-ethanolamine, CDP-choline, NAD(+), diadenosine pentaphosphate, GTP, UTP, ATP, or CTP. | 0.459 |
napC | nudK | b2202 | b2467 | Quinol dehydrogenase, electron source for NapAB; Mediates electron flow from quinones to the NapAB complex. | GDP-mannose pyrophosphatase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. Can also hydrolyze the pyrophosphate bond of other sugar nucleotides such as IDP-ribose, GDP-glucose, and to a lesser extent, ADP-ribose, ADP-glucose and UDP-glucose. Shows no activity toward Nudix substrates FAD, CDP-ethanolamine, CDP-choline, NAD(+), diadenosine pentaphosphate, GTP, UTP, ATP, or CTP. | 0.594 |
nnr | birA | b4167 | b3973 | Bifunctional NAD(P)H-hydrate repair enzyme; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the N-terminal section; belongs to the NnrE/AIBP family. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.495 |
nnr | nudK | b4167 | b2467 | Bifunctional NAD(P)H-hydrate repair enzyme; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the N-terminal section; belongs to the NnrE/AIBP family. | GDP-mannose pyrophosphatase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. Can also hydrolyze the pyrophosphate bond of other sugar nucleotides such as IDP-ribose, GDP-glucose, and to a lesser extent, ADP-ribose, ADP-glucose and UDP-glucose. Shows no activity toward Nudix substrates FAD, CDP-ethanolamine, CDP-choline, NAD(+), diadenosine pentaphosphate, GTP, UTP, ATP, or CTP. | 0.774 |
nudI | nudJ | b2251 | b1134 | Nucleoside triphosphatase; Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP). | Bifunctional thiamine pyrimidine pyrophosphate hydrolase and thiamine pyrophosphate hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P), and hydrolysis of thiamine pyrophosphate (TPP) to thiamine monophosphate (TMP). Can hydrolyze other substrates such as MeO-HMP-PP, CF(3)-HMP-PP and MeO-TPP. Is also a non-specific nucleoside tri- and diphosphatase that releases inorganic orthophosphate; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.892 |
nudI | nudK | b2251 | b2467 | Nucleoside triphosphatase; Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP). | GDP-mannose pyrophosphatase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. Can also hydrolyze the pyrophosphate bond of other sugar nucleotides such as IDP-ribose, GDP-glucose, and to a lesser extent, ADP-ribose, ADP-glucose and UDP-glucose. Shows no activity toward Nudix substrates FAD, CDP-ethanolamine, CDP-choline, NAD(+), diadenosine pentaphosphate, GTP, UTP, ATP, or CTP. | 0.533 |
nudI | wcaH | b2251 | b2051 | Nucleoside triphosphatase; Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP). | GDP-mannose mannosyl hydrolase; Hydrolyzes both GDP-mannose and GDP-glucose. Could participate in the regulation of cell wall biosynthesis by influencing the concentration of GDP-mannose or GDP-glucose in the cell. Might also be involved in the biosynthesis of the slime polysaccharide colanic acid; Belongs to the Nudix hydrolase family. | 0.633 |
nudI | ypfG | b2251 | b2466 | Nucleoside triphosphatase; Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP). | DUF1176 family protein. | 0.655 |
nudJ | nudI | b1134 | b2251 | Bifunctional thiamine pyrimidine pyrophosphate hydrolase and thiamine pyrophosphate hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P), and hydrolysis of thiamine pyrophosphate (TPP) to thiamine monophosphate (TMP). Can hydrolyze other substrates such as MeO-HMP-PP, CF(3)-HMP-PP and MeO-TPP. Is also a non-specific nucleoside tri- and diphosphatase that releases inorganic orthophosphate; Belongs to the Nudix hydrolase family. NudJ subfamily. | Nucleoside triphosphatase; Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP). | 0.892 |
nudJ | nudK | b1134 | b2467 | Bifunctional thiamine pyrimidine pyrophosphate hydrolase and thiamine pyrophosphate hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P), and hydrolysis of thiamine pyrophosphate (TPP) to thiamine monophosphate (TMP). Can hydrolyze other substrates such as MeO-HMP-PP, CF(3)-HMP-PP and MeO-TPP. Is also a non-specific nucleoside tri- and diphosphatase that releases inorganic orthophosphate; Belongs to the Nudix hydrolase family. NudJ subfamily. | GDP-mannose pyrophosphatase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. Can also hydrolyze the pyrophosphate bond of other sugar nucleotides such as IDP-ribose, GDP-glucose, and to a lesser extent, ADP-ribose, ADP-glucose and UDP-glucose. Shows no activity toward Nudix substrates FAD, CDP-ethanolamine, CDP-choline, NAD(+), diadenosine pentaphosphate, GTP, UTP, ATP, or CTP. | 0.648 |
nudJ | wcaH | b1134 | b2051 | Bifunctional thiamine pyrimidine pyrophosphate hydrolase and thiamine pyrophosphate hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P), and hydrolysis of thiamine pyrophosphate (TPP) to thiamine monophosphate (TMP). Can hydrolyze other substrates such as MeO-HMP-PP, CF(3)-HMP-PP and MeO-TPP. Is also a non-specific nucleoside tri- and diphosphatase that releases inorganic orthophosphate; Belongs to the Nudix hydrolase family. NudJ subfamily. | GDP-mannose mannosyl hydrolase; Hydrolyzes both GDP-mannose and GDP-glucose. Could participate in the regulation of cell wall biosynthesis by influencing the concentration of GDP-mannose or GDP-glucose in the cell. Might also be involved in the biosynthesis of the slime polysaccharide colanic acid; Belongs to the Nudix hydrolase family. | 0.644 |
nudK | aegA | b2467 | b2468 | GDP-mannose pyrophosphatase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. Can also hydrolyze the pyrophosphate bond of other sugar nucleotides such as IDP-ribose, GDP-glucose, and to a lesser extent, ADP-ribose, ADP-glucose and UDP-glucose. Shows no activity toward Nudix substrates FAD, CDP-ethanolamine, CDP-choline, NAD(+), diadenosine pentaphosphate, GTP, UTP, ATP, or CTP. | Putative oxidoreductase, FeS binding subunit/NAD/FAD-binding subunit. | 0.601 |
nudK | birA | b2467 | b3973 | GDP-mannose pyrophosphatase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. Can also hydrolyze the pyrophosphate bond of other sugar nucleotides such as IDP-ribose, GDP-glucose, and to a lesser extent, ADP-ribose, ADP-glucose and UDP-glucose. Shows no activity toward Nudix substrates FAD, CDP-ethanolamine, CDP-choline, NAD(+), diadenosine pentaphosphate, GTP, UTP, ATP, or CTP. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.534 |
nudK | fabD | b2467 | b1092 | GDP-mannose pyrophosphatase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. Can also hydrolyze the pyrophosphate bond of other sugar nucleotides such as IDP-ribose, GDP-glucose, and to a lesser extent, ADP-ribose, ADP-glucose and UDP-glucose. Shows no activity toward Nudix substrates FAD, CDP-ethanolamine, CDP-choline, NAD(+), diadenosine pentaphosphate, GTP, UTP, ATP, or CTP. | malonyl-CoA-[acyl-carrier-protein] transacylase; Belongs to the FabD family. | 0.459 |
nudK | napC | b2467 | b2202 | GDP-mannose pyrophosphatase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. Can also hydrolyze the pyrophosphate bond of other sugar nucleotides such as IDP-ribose, GDP-glucose, and to a lesser extent, ADP-ribose, ADP-glucose and UDP-glucose. Shows no activity toward Nudix substrates FAD, CDP-ethanolamine, CDP-choline, NAD(+), diadenosine pentaphosphate, GTP, UTP, ATP, or CTP. | Quinol dehydrogenase, electron source for NapAB; Mediates electron flow from quinones to the NapAB complex. | 0.594 |