node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
folD | purC | b0529 | b2476 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. This enzyme is specific for NADP. | Phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase; Protein involved in purine nucleotide biosynthetic process. | 0.493 |
folD | purD | b0529 | b4005 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. This enzyme is specific for NADP. | Phosphoribosylglycinamide synthetase = GAR synthetase; Protein involved in purine nucleotide biosynthetic process; Belongs to the GARS family. | 0.947 |
folD | purE | b0529 | b0523 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. This enzyme is specific for NADP. | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the AIR carboxylase family. Class I subfamily. | 0.655 |
folD | purF | b0529 | b2312 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. This enzyme is specific for NADP. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. Can also use NH(3) in place of glutamine. | 0.586 |
folD | purH | b0529 | b4006 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. This enzyme is specific for NADP. | IMP cyclohydrolase and phosphoribosylaminoimidazolecarboxamide formyltransferase; Protein involved in purine nucleotide biosynthetic process and nucleobase, nucleoside and nucleotide interconversion. | 0.980 |
folD | purK | b0529 | b0522 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. This enzyme is specific for NADP. | N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. | 0.593 |
folD | purL | b0529 | b2557 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. This enzyme is specific for NADP. | Phosphoribosylformyl-glycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.802 |
folD | purM | b0529 | b2499 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. This enzyme is specific for NADP. | Phosphoribosylaminoimidazole synthetase = AIR synthetase; Protein involved in purine nucleotide biosynthetic process; Belongs to the AIR synthase family. | 0.641 |
folD | purN | b0529 | b2500 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. This enzyme is specific for NADP. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate; Belongs to the GART family. | 0.988 |
folD | purT | b0529 | b1849 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. This enzyme is specific for NADP. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. PurT is also able to cleave acetyl phosphate and carbamoyl phosphate to produce ATP with acetate and carbamate, respectively; Belongs to the PurK/PurT family. | 0.913 |
purC | folD | b2476 | b0529 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase; Protein involved in purine nucleotide biosynthetic process. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. This enzyme is specific for NADP. | 0.493 |
purC | purD | b2476 | b4005 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase; Protein involved in purine nucleotide biosynthetic process. | Phosphoribosylglycinamide synthetase = GAR synthetase; Protein involved in purine nucleotide biosynthetic process; Belongs to the GARS family. | 0.994 |
purC | purE | b2476 | b0523 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase; Protein involved in purine nucleotide biosynthetic process. | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the AIR carboxylase family. Class I subfamily. | 0.999 |
purC | purF | b2476 | b2312 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase; Protein involved in purine nucleotide biosynthetic process. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. Can also use NH(3) in place of glutamine. | 0.991 |
purC | purH | b2476 | b4006 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase; Protein involved in purine nucleotide biosynthetic process. | IMP cyclohydrolase and phosphoribosylaminoimidazolecarboxamide formyltransferase; Protein involved in purine nucleotide biosynthetic process and nucleobase, nucleoside and nucleotide interconversion. | 0.997 |
purC | purK | b2476 | b0522 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase; Protein involved in purine nucleotide biosynthetic process. | N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. | 0.998 |
purC | purL | b2476 | b2557 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase; Protein involved in purine nucleotide biosynthetic process. | Phosphoribosylformyl-glycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.998 |
purC | purM | b2476 | b2499 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase; Protein involved in purine nucleotide biosynthetic process. | Phosphoribosylaminoimidazole synthetase = AIR synthetase; Protein involved in purine nucleotide biosynthetic process; Belongs to the AIR synthase family. | 0.998 |
purC | purN | b2476 | b2500 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase; Protein involved in purine nucleotide biosynthetic process. | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate; Belongs to the GART family. | 0.993 |
purC | purT | b2476 | b1849 | Phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase; Protein involved in purine nucleotide biosynthetic process. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. PurT is also able to cleave acetyl phosphate and carbamoyl phosphate to produce ATP with acetate and carbamate, respectively; Belongs to the PurK/PurT family. | 0.867 |