node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aaeR | hcaR | b3243 | b2537 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | 0.766 |
aaeR | lrhA | b3243 | b2289 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | Transcriptional repressor of flagellar, motility and chemotaxis genes; Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon. | 0.794 |
dmlR | hcaR | b1799 | b2537 | Transcriptional activator of dmlA; Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression. | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | 0.804 |
dmlR | lrhA | b1799 | b2289 | Transcriptional activator of dmlA; Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression. | Transcriptional repressor of flagellar, motility and chemotaxis genes; Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon. | 0.591 |
feaR | glcC | b1384 | b2980 | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | Glycolate-inducible glc operon transcriptional repressor; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity. Also negatively regulates the transcription of its own gene. Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector. | 0.545 |
feaR | hcaR | b1384 | b2537 | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | 0.759 |
feaR | mhpR | b1384 | b0346 | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | Mhp operon transcriptional activator; Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway. | 0.476 |
glcC | feaR | b2980 | b1384 | Glycolate-inducible glc operon transcriptional repressor; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity. Also negatively regulates the transcription of its own gene. Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector. | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | 0.545 |
glcC | hcaR | b2980 | b2537 | Glycolate-inducible glc operon transcriptional repressor; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity. Also negatively regulates the transcription of its own gene. Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector. | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | 0.846 |
glcC | mhpR | b2980 | b0346 | Glycolate-inducible glc operon transcriptional repressor; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity. Also negatively regulates the transcription of its own gene. Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector. | Mhp operon transcriptional activator; Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway. | 0.867 |
hcaC | hcaE | b2540 | b2538 | 3-phenylpropionate dioxygenase, ferredoxin subunit; Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively. This protein seems to be a 2Fe-2S ferredoxin. | 3-phenylpropionate dioxygenase, large (alpha) subunit; Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3- phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively. | 0.998 |
hcaC | hcaR | b2540 | b2537 | 3-phenylpropionate dioxygenase, ferredoxin subunit; Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively. This protein seems to be a 2Fe-2S ferredoxin. | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | 0.908 |
hcaE | hcaC | b2538 | b2540 | 3-phenylpropionate dioxygenase, large (alpha) subunit; Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3- phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively. | 3-phenylpropionate dioxygenase, ferredoxin subunit; Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively. This protein seems to be a 2Fe-2S ferredoxin. | 0.998 |
hcaE | hcaR | b2538 | b2537 | 3-phenylpropionate dioxygenase, large (alpha) subunit; Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3- phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively. | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | 0.897 |
hcaE | mhpR | b2538 | b0346 | 3-phenylpropionate dioxygenase, large (alpha) subunit; Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3- phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively. | Mhp operon transcriptional activator; Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway. | 0.435 |
hcaR | aaeR | b2537 | b3243 | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | 0.766 |
hcaR | dmlR | b2537 | b1799 | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | Transcriptional activator of dmlA; Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression. | 0.804 |
hcaR | feaR | b2537 | b1384 | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. | 0.759 |
hcaR | glcC | b2537 | b2980 | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | Glycolate-inducible glc operon transcriptional repressor; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity. Also negatively regulates the transcription of its own gene. Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector. | 0.846 |
hcaR | hcaC | b2537 | b2540 | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. | 3-phenylpropionate dioxygenase, ferredoxin subunit; Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively. This protein seems to be a 2Fe-2S ferredoxin. | 0.908 |