node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ratA | ratB | b2619 | b2618 | Toxic UPF0083 family protein inhibitor of 70S ribosome formation; Toxic component of a type II toxin-antitoxin (TA) system. Binds to 50S ribosomal subunits, preventing them from associating with 30S subunits to form 70S ribosomes and reducing polysomes. It does not cause ribosomes to dissociate however. The antibiotic paromomycin blocks the anti-association activity of RatA. Overexpression results in inhibition of growth in liquid cultures, and in a decrease in protein translation. The other gene of this operon, ratB, is not the cognate antitoxin in this strain; in CFT073 however it do [...] | UPF0125 family protein; Does not function as an antitoxin to the upstream RatA toxin; Belongs to the UPF0125 (RnfH) family. | 0.988 |
ratA | tomB | b2619 | b0461 | Toxic UPF0083 family protein inhibitor of 70S ribosome formation; Toxic component of a type II toxin-antitoxin (TA) system. Binds to 50S ribosomal subunits, preventing them from associating with 30S subunits to form 70S ribosomes and reducing polysomes. It does not cause ribosomes to dissociate however. The antibiotic paromomycin blocks the anti-association activity of RatA. Overexpression results in inhibition of growth in liquid cultures, and in a decrease in protein translation. The other gene of this operon, ratB, is not the cognate antitoxin in this strain; in CFT073 however it do [...] | Hha toxicity attenuator; Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA. | 0.546 |
ratA | yefM | b2619 | b2017 | Toxic UPF0083 family protein inhibitor of 70S ribosome formation; Toxic component of a type II toxin-antitoxin (TA) system. Binds to 50S ribosomal subunits, preventing them from associating with 30S subunits to form 70S ribosomes and reducing polysomes. It does not cause ribosomes to dissociate however. The antibiotic paromomycin blocks the anti-association activity of RatA. Overexpression results in inhibition of growth in liquid cultures, and in a decrease in protein translation. The other gene of this operon, ratB, is not the cognate antitoxin in this strain; in CFT073 however it do [...] | Antitoxin of the YoeB-YefM toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of the YoeB toxin. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor. | 0.640 |
ratB | ratA | b2618 | b2619 | UPF0125 family protein; Does not function as an antitoxin to the upstream RatA toxin; Belongs to the UPF0125 (RnfH) family. | Toxic UPF0083 family protein inhibitor of 70S ribosome formation; Toxic component of a type II toxin-antitoxin (TA) system. Binds to 50S ribosomal subunits, preventing them from associating with 30S subunits to form 70S ribosomes and reducing polysomes. It does not cause ribosomes to dissociate however. The antibiotic paromomycin blocks the anti-association activity of RatA. Overexpression results in inhibition of growth in liquid cultures, and in a decrease in protein translation. The other gene of this operon, ratB, is not the cognate antitoxin in this strain; in CFT073 however it do [...] | 0.988 |
ratB | rsxA | b2618 | b1627 | UPF0125 family protein; Does not function as an antitoxin to the upstream RatA toxin; Belongs to the UPF0125 (RnfH) family. | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. | 0.658 |
ratB | rsxB | b2618 | b1628 | UPF0125 family protein; Does not function as an antitoxin to the upstream RatA toxin; Belongs to the UPF0125 (RnfH) family. | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. | 0.840 |
ratB | rsxC | b2618 | b1629 | UPF0125 family protein; Does not function as an antitoxin to the upstream RatA toxin; Belongs to the UPF0125 (RnfH) family. | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. | 0.714 |
ratB | rsxD | b2618 | b1630 | UPF0125 family protein; Does not function as an antitoxin to the upstream RatA toxin; Belongs to the UPF0125 (RnfH) family. | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. Belongs to the NqrB/RnfD family. | 0.731 |
ratB | rsxE | b2618 | b1632 | UPF0125 family protein; Does not function as an antitoxin to the upstream RatA toxin; Belongs to the UPF0125 (RnfH) family. | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. | 0.651 |
ratB | rsxG | b2618 | b1631 | UPF0125 family protein; Does not function as an antitoxin to the upstream RatA toxin; Belongs to the UPF0125 (RnfH) family. | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. Belongs to the RnfG family. | 0.798 |
ratB | tomB | b2618 | b0461 | UPF0125 family protein; Does not function as an antitoxin to the upstream RatA toxin; Belongs to the UPF0125 (RnfH) family. | Hha toxicity attenuator; Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA. | 0.736 |
ratB | yefM | b2618 | b2017 | UPF0125 family protein; Does not function as an antitoxin to the upstream RatA toxin; Belongs to the UPF0125 (RnfH) family. | Antitoxin of the YoeB-YefM toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of the YoeB toxin. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor. | 0.648 |
ratB | yggT | b2618 | b2952 | UPF0125 family protein; Does not function as an antitoxin to the upstream RatA toxin; Belongs to the UPF0125 (RnfH) family. | Conserved hypothetical integral membrane protein. | 0.639 |
rsxA | ratB | b1627 | b2618 | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. | UPF0125 family protein; Does not function as an antitoxin to the upstream RatA toxin; Belongs to the UPF0125 (RnfH) family. | 0.658 |
rsxA | rsxB | b1627 | b1628 | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. | 0.999 |
rsxA | rsxC | b1627 | b1629 | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. | 0.999 |
rsxA | rsxD | b1627 | b1630 | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. Belongs to the NqrB/RnfD family. | 0.999 |
rsxA | rsxE | b1627 | b1632 | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. | 0.981 |
rsxA | rsxG | b1627 | b1631 | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. Belongs to the RnfG family. | 0.998 |
rsxB | ratB | b1628 | b2618 | SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. | UPF0125 family protein; Does not function as an antitoxin to the upstream RatA toxin; Belongs to the UPF0125 (RnfH) family. | 0.840 |