node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
copA | pfo | b0484 | b1378 | Copper transporter; [Copper-exporting P-type ATPase]: Exports Cu(+) from the cytoplasm to the periplasm. Binds 2 Cu(+) ions per monomer, which are transferred to periplasmic copper chaperone CusF upon ATP hydrolysis. In vitro an excess of CusF over CopA is required for efficient transfer. May also be involved in silver export. | Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin. | 0.605 |
copA | ygaP | b0484 | b2668 | Copper transporter; [Copper-exporting P-type ATPase]: Exports Cu(+) from the cytoplasm to the periplasm. Binds 2 Cu(+) ions per monomer, which are transferred to periplasmic copper chaperone CusF upon ATP hydrolysis. In vitro an excess of CusF over CopA is required for efficient transfer. May also be involved in silver export. | DUF2892 family inner membrane rhodanese. | 0.481 |
copA | ygaV | b0484 | b2667 | Copper transporter; [Copper-exporting P-type ATPase]: Exports Cu(+) from the cytoplasm to the periplasm. Binds 2 Cu(+) ions per monomer, which are transferred to periplasmic copper chaperone CusF upon ATP hydrolysis. In vitro an excess of CusF over CopA is required for efficient transfer. May also be involved in silver export. | Tributyltin-inducible repressor of ygaVP; Functions as transcription repressor. | 0.608 |
copA | zntA | b0484 | b3469 | Copper transporter; [Copper-exporting P-type ATPase]: Exports Cu(+) from the cytoplasm to the periplasm. Binds 2 Cu(+) ions per monomer, which are transferred to periplasmic copper chaperone CusF upon ATP hydrolysis. In vitro an excess of CusF over CopA is required for efficient transfer. May also be involved in silver export. | Zinc, cobalt and lead efflux system; Confers resistance to zinc, cadmium and lead. Couples the hydrolysis of ATP with the export of zinc, cadmium or lead, with highest activity when the metals are present as metal-thiolate complexes. Can also bind nickel, copper, cobalt and mercury. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | 0.875 |
pfo | copA | b1378 | b0484 | Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin. | Copper transporter; [Copper-exporting P-type ATPase]: Exports Cu(+) from the cytoplasm to the periplasm. Binds 2 Cu(+) ions per monomer, which are transferred to periplasmic copper chaperone CusF upon ATP hydrolysis. In vitro an excess of CusF over CopA is required for efficient transfer. May also be involved in silver export. | 0.605 |
pfo | ygaV | b1378 | b2667 | Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin. | Tributyltin-inducible repressor of ygaVP; Functions as transcription repressor. | 0.431 |
pfo | zntA | b1378 | b3469 | Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin. | Zinc, cobalt and lead efflux system; Confers resistance to zinc, cadmium and lead. Couples the hydrolysis of ATP with the export of zinc, cadmium or lead, with highest activity when the metals are present as metal-thiolate complexes. Can also bind nickel, copper, cobalt and mercury. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. | 0.446 |
pspC | pspD | b1306 | b1307 | Psp operon transcription co-activator; The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspC is involved in transcription regulation; Belongs to the phageshock PspC family. | Peripheral inner membrane phage-shock protein; The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. | 0.999 |
pspC | ygaV | b1306 | b2667 | Psp operon transcription co-activator; The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspC is involved in transcription regulation; Belongs to the phageshock PspC family. | Tributyltin-inducible repressor of ygaVP; Functions as transcription repressor. | 0.403 |
pspD | pspC | b1307 | b1306 | Peripheral inner membrane phage-shock protein; The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. | Psp operon transcription co-activator; The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspC is involved in transcription regulation; Belongs to the phageshock PspC family. | 0.999 |
pspD | ygaV | b1307 | b2667 | Peripheral inner membrane phage-shock protein; The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. | Tributyltin-inducible repressor of ygaVP; Functions as transcription repressor. | 0.530 |
yejG | ygaV | b2181 | b2667 | Uncharacterized protein. | Tributyltin-inducible repressor of ygaVP; Functions as transcription repressor. | 0.644 |
ygaP | copA | b2668 | b0484 | DUF2892 family inner membrane rhodanese. | Copper transporter; [Copper-exporting P-type ATPase]: Exports Cu(+) from the cytoplasm to the periplasm. Binds 2 Cu(+) ions per monomer, which are transferred to periplasmic copper chaperone CusF upon ATP hydrolysis. In vitro an excess of CusF over CopA is required for efficient transfer. May also be involved in silver export. | 0.481 |
ygaP | ygaV | b2668 | b2667 | DUF2892 family inner membrane rhodanese. | Tributyltin-inducible repressor of ygaVP; Functions as transcription repressor. | 0.976 |
ygaP | yqaE | b2668 | b2666 | DUF2892 family inner membrane rhodanese. | cyaR sRNA-regulated protein. | 0.519 |
ygaU | ygaV | b2665 | b2667 | Uncharacterized protein; Highly specific potassium binding protein that is required for normal growth in the presence of high levels of external K(+). May act as a sensor of cytoplasmic K(+) concentration. Binds a single K(+) ion, which induces a large conformational change. Can also bind the larger alkali metal ions Rb(+) and Cs(+), and NH(4)(+). May be involved in the regulation of peptidoglycan cross-linking. | Tributyltin-inducible repressor of ygaVP; Functions as transcription repressor. | 0.405 |
ygaU | yqaE | b2665 | b2666 | Uncharacterized protein; Highly specific potassium binding protein that is required for normal growth in the presence of high levels of external K(+). May act as a sensor of cytoplasmic K(+) concentration. Binds a single K(+) ion, which induces a large conformational change. Can also bind the larger alkali metal ions Rb(+) and Cs(+), and NH(4)(+). May be involved in the regulation of peptidoglycan cross-linking. | cyaR sRNA-regulated protein. | 0.620 |
ygaV | copA | b2667 | b0484 | Tributyltin-inducible repressor of ygaVP; Functions as transcription repressor. | Copper transporter; [Copper-exporting P-type ATPase]: Exports Cu(+) from the cytoplasm to the periplasm. Binds 2 Cu(+) ions per monomer, which are transferred to periplasmic copper chaperone CusF upon ATP hydrolysis. In vitro an excess of CusF over CopA is required for efficient transfer. May also be involved in silver export. | 0.608 |
ygaV | pfo | b2667 | b1378 | Tributyltin-inducible repressor of ygaVP; Functions as transcription repressor. | Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin. | 0.431 |
ygaV | pspC | b2667 | b1306 | Tributyltin-inducible repressor of ygaVP; Functions as transcription repressor. | Psp operon transcription co-activator; The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspC is involved in transcription regulation; Belongs to the phageshock PspC family. | 0.403 |