node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
alaE | dadA | b2670 | b1189 | Alanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family. | D-amino acid dehydrogenase; Catalyzes the oxidative deamination of D-amino acids. Has broad substrate specificity; is mostly active on D-alanine, and to a lesser extent, on several other D-amino acids such as D-methionine, D- serine and D-proline, but not on L-alanine. Participates in the utilization of L-alanine and D-alanine as the sole source of carbon, nitrogen and energy for growth. Is also able to oxidize D-amino acid analogs such as 3,4-dehydro-D-proline, D-2-aminobutyrate, D-norvaline, D-norleucine, cis-4-hydroxy-D-proline, and DL-ethionine. | 0.730 |
alaE | dadX | b2670 | b1190 | Alanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family. | Alanine racemase, catabolic, PLP-binding; Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA. | 0.530 |
alaE | leuE | b2670 | b1798 | Alanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family. | Leucine efflux protein; Exporter of leucine. Can also transport its natural analog L- alpha-amino-n-butyric acid and some other structurally unrelated amino acids. | 0.794 |
alaE | lrp | b2670 | b0889 | Alanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family. | Leucine-responsive global transcriptional regulator; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes. | 0.526 |
alaE | yahN | b2670 | b0328 | Alanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family. | Amino acid exporter for proline, lysine, glutamate, homoserine; Putative cytochrome subunit of dehydrogenase. | 0.732 |
alaE | yddG | b2670 | b1473 | Alanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family. | Aromatic amino acid exporter YddG; Probable efflux pump. Overexpression confers resistance to phenylalanine and increases export of phenylalanine, tyrosine and tryptophan; Belongs to the drug/metabolite transporter (DMT) superfamily. Aromatic amino acid/paraquat exporter (ArAA/P-E) (TC 2.A.7.17) family. | 0.645 |
alaE | ydjN | b2670 | b1729 | Alanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family. | Putative transporter; Involved in L-cystine transport. Can probably also transport L-cysteine. Mediates accumulation of the toxic compounds L- selenaproline (SCA) and L-selenocystine (SeCys). Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. | 0.509 |
alaE | yjcB | b2670 | b4060 | Alanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family. | Putative inner membrane protein. | 0.594 |
alaE | yoeI | b2670 | b4678 | Alanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family. | Uncharacterized protein. | 0.521 |
alaE | ytfF | b2670 | b4210 | Alanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family. | DMT transporter family inner membrane protein; Putative transmembrane subunit. | 0.809 |
dadA | alaE | b1189 | b2670 | D-amino acid dehydrogenase; Catalyzes the oxidative deamination of D-amino acids. Has broad substrate specificity; is mostly active on D-alanine, and to a lesser extent, on several other D-amino acids such as D-methionine, D- serine and D-proline, but not on L-alanine. Participates in the utilization of L-alanine and D-alanine as the sole source of carbon, nitrogen and energy for growth. Is also able to oxidize D-amino acid analogs such as 3,4-dehydro-D-proline, D-2-aminobutyrate, D-norvaline, D-norleucine, cis-4-hydroxy-D-proline, and DL-ethionine. | Alanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family. | 0.730 |
dadA | dadX | b1189 | b1190 | D-amino acid dehydrogenase; Catalyzes the oxidative deamination of D-amino acids. Has broad substrate specificity; is mostly active on D-alanine, and to a lesser extent, on several other D-amino acids such as D-methionine, D- serine and D-proline, but not on L-alanine. Participates in the utilization of L-alanine and D-alanine as the sole source of carbon, nitrogen and energy for growth. Is also able to oxidize D-amino acid analogs such as 3,4-dehydro-D-proline, D-2-aminobutyrate, D-norvaline, D-norleucine, cis-4-hydroxy-D-proline, and DL-ethionine. | Alanine racemase, catabolic, PLP-binding; Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA. | 0.999 |
dadX | alaE | b1190 | b2670 | Alanine racemase, catabolic, PLP-binding; Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA. | Alanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family. | 0.530 |
dadX | dadA | b1190 | b1189 | Alanine racemase, catabolic, PLP-binding; Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA. | D-amino acid dehydrogenase; Catalyzes the oxidative deamination of D-amino acids. Has broad substrate specificity; is mostly active on D-alanine, and to a lesser extent, on several other D-amino acids such as D-methionine, D- serine and D-proline, but not on L-alanine. Participates in the utilization of L-alanine and D-alanine as the sole source of carbon, nitrogen and energy for growth. Is also able to oxidize D-amino acid analogs such as 3,4-dehydro-D-proline, D-2-aminobutyrate, D-norvaline, D-norleucine, cis-4-hydroxy-D-proline, and DL-ethionine. | 0.999 |
leuE | alaE | b1798 | b2670 | Leucine efflux protein; Exporter of leucine. Can also transport its natural analog L- alpha-amino-n-butyric acid and some other structurally unrelated amino acids. | Alanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family. | 0.794 |
leuE | lrp | b1798 | b0889 | Leucine efflux protein; Exporter of leucine. Can also transport its natural analog L- alpha-amino-n-butyric acid and some other structurally unrelated amino acids. | Leucine-responsive global transcriptional regulator; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes. | 0.471 |
leuE | yahN | b1798 | b0328 | Leucine efflux protein; Exporter of leucine. Can also transport its natural analog L- alpha-amino-n-butyric acid and some other structurally unrelated amino acids. | Amino acid exporter for proline, lysine, glutamate, homoserine; Putative cytochrome subunit of dehydrogenase. | 0.412 |
leuE | yddG | b1798 | b1473 | Leucine efflux protein; Exporter of leucine. Can also transport its natural analog L- alpha-amino-n-butyric acid and some other structurally unrelated amino acids. | Aromatic amino acid exporter YddG; Probable efflux pump. Overexpression confers resistance to phenylalanine and increases export of phenylalanine, tyrosine and tryptophan; Belongs to the drug/metabolite transporter (DMT) superfamily. Aromatic amino acid/paraquat exporter (ArAA/P-E) (TC 2.A.7.17) family. | 0.803 |
leuE | ytfF | b1798 | b4210 | Leucine efflux protein; Exporter of leucine. Can also transport its natural analog L- alpha-amino-n-butyric acid and some other structurally unrelated amino acids. | DMT transporter family inner membrane protein; Putative transmembrane subunit. | 0.823 |
lrp | alaE | b0889 | b2670 | Leucine-responsive global transcriptional regulator; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes. | Alanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family. | 0.526 |