STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
proXGlycine betaine/proline ABC transporter periplasmic binding protein; Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Binds glycine betaine and proline betaine with high affinity. (330 aa)    
Predicted Functional Partners:
proV
Glycine betaine/proline ABC transporter periplasmic binding protein; Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Probably responsible for energy coupling to the transport system (Probable).
 
 0.999
proW
Glycine betaine/proline ABC transporter permease; Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Probably responsible for the translocation of the substrate across the membrane (Probable); Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
 
 0.999
proP
Proline/glycine betaine transporter; Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response; Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.
      
 0.790
yehY
Putative ABC transporter permease; Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for the translocation of the substrate across the membrane.
 
 
 0.763
osmF
Putative ABC transporter periplasmic binding protein; Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Binds glycine betaine with low affinity. Belongs to the OsmX family.
   
 
 0.743
yehW
Putative ABC transporter permease; Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
 
 
 0.718
betT
Choline transporter of high affinity; High-affinity uptake of choline driven by a proton-motive force; Belongs to the BCCT transporter (TC 2.A.15) family.
     
 0.686
yehX
Putative ABC transporter ATPase; Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for energy coupling to the transport system.
  
 
 0.634
modF
Molybdate ABC transporter ATPase; Probably not involved in the transport of molybdenum into the cell; Belongs to the ABC transporter superfamily.
  
  
  0.618
yhdX
Putative amino-acid ABC transporter permease protein YhdX; Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino acid; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
  
  
  0.600
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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