node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
endA | gshB | b2945 | b2947 | DNA-specific endonuclease I; Has double-strand break activity; Belongs to the EndA/NucM nuclease family. | Protein involved in glutathione biosynthetic process. | 0.621 |
endA | lacZ | b2945 | b0344 | DNA-specific endonuclease I; Has double-strand break activity; Belongs to the EndA/NucM nuclease family. | beta-D-galactosidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family. | 0.681 |
endA | nfi | b2945 | b3998 | DNA-specific endonuclease I; Has double-strand break activity; Belongs to the EndA/NucM nuclease family. | Endonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Has a wide substrate spectrum. In addition to deoxyinosine- containing DNA, the enzyme cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures. Participates in the excision repair of hypoxanthine and xanthine (deaminated adenine and guanine) in DNA. It thereby reduces the mutagenic effects of ni [...] | 0.623 |
endA | recA | b2945 | b2699 | DNA-specific endonuclease I; Has double-strand break activity; Belongs to the EndA/NucM nuclease family. | DNA recombination and repair protein; Required for homologous recombination and the bypass of mutagenic DNA lesions by the SOS response. Catalyzes ATP-driven homologous pairing and strand exchange of DNA molecules necessary for DNA recombinational repair. Catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single- stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in resp [...] | 0.645 |
endA | rna | b2945 | b0611 | DNA-specific endonuclease I; Has double-strand break activity; Belongs to the EndA/NucM nuclease family. | Ribonuclease I; One of the few RNases that cleaves the phosphodiester bond between any two nucleotide. Shows a preference for cytidylic or guanylic acid. | 0.604 |
endA | rsmE | b2945 | b2946 | DNA-specific endonuclease I; Has double-strand break activity; Belongs to the EndA/NucM nuclease family. | 16S rRNA m(3)U1498 methyltransferase, SAM-dependent; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.854 |
endA | ruvC | b2945 | b1863 | DNA-specific endonuclease I; Has double-strand break activity; Belongs to the EndA/NucM nuclease family. | Component of RuvABC resolvasome, endonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.901 |
endA | vsr | b2945 | b1960 | DNA-specific endonuclease I; Has double-strand break activity; Belongs to the EndA/NucM nuclease family. | DNA mismatch endonuclease of very short patch repair; Deamination of 5-methylcytosine in DNA results in T/G mismatches. If unrepaired, these mismatches can lead to C-to-C transition mutations. The very short patch (VSP) repair process in E.coli counteracts the mutagenic process by repairing the mismatches in favor of the G-containing strand. This enzyme is an endonuclease that nicks double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the thymidine residue that is mismatched to 2'-deoxyguanosine. The incision is mismatch-dependent and strand-specific; Belongs to the vsr [...] | 0.624 |
endA | xthA | b2945 | b1749 | DNA-specific endonuclease I; Has double-strand break activity; Belongs to the EndA/NucM nuclease family. | Exonuclease III; Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'- 5'-exonuclease, 3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease H activities. | 0.648 |
endA | yggI | b2945 | b2944 | DNA-specific endonuclease I; Has double-strand break activity; Belongs to the EndA/NucM nuclease family. | Zn-dependent metalloprotease-related protein; Involved in bolA gene expression at the stationary phase. | 0.620 |
gshB | endA | b2947 | b2945 | Protein involved in glutathione biosynthetic process. | DNA-specific endonuclease I; Has double-strand break activity; Belongs to the EndA/NucM nuclease family. | 0.621 |
gshB | rsmE | b2947 | b2946 | Protein involved in glutathione biosynthetic process. | 16S rRNA m(3)U1498 methyltransferase, SAM-dependent; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.863 |
gshB | yggI | b2947 | b2944 | Protein involved in glutathione biosynthetic process. | Zn-dependent metalloprotease-related protein; Involved in bolA gene expression at the stationary phase. | 0.429 |
lacZ | endA | b0344 | b2945 | beta-D-galactosidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family. | DNA-specific endonuclease I; Has double-strand break activity; Belongs to the EndA/NucM nuclease family. | 0.681 |
lacZ | recA | b0344 | b2699 | beta-D-galactosidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family. | DNA recombination and repair protein; Required for homologous recombination and the bypass of mutagenic DNA lesions by the SOS response. Catalyzes ATP-driven homologous pairing and strand exchange of DNA molecules necessary for DNA recombinational repair. Catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single- stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in resp [...] | 0.907 |
lacZ | rna | b0344 | b0611 | beta-D-galactosidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family. | Ribonuclease I; One of the few RNases that cleaves the phosphodiester bond between any two nucleotide. Shows a preference for cytidylic or guanylic acid. | 0.607 |
nfi | endA | b3998 | b2945 | Endonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Has a wide substrate spectrum. In addition to deoxyinosine- containing DNA, the enzyme cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures. Participates in the excision repair of hypoxanthine and xanthine (deaminated adenine and guanine) in DNA. It thereby reduces the mutagenic effects of ni [...] | DNA-specific endonuclease I; Has double-strand break activity; Belongs to the EndA/NucM nuclease family. | 0.623 |
nfi | recA | b3998 | b2699 | Endonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Has a wide substrate spectrum. In addition to deoxyinosine- containing DNA, the enzyme cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures. Participates in the excision repair of hypoxanthine and xanthine (deaminated adenine and guanine) in DNA. It thereby reduces the mutagenic effects of ni [...] | DNA recombination and repair protein; Required for homologous recombination and the bypass of mutagenic DNA lesions by the SOS response. Catalyzes ATP-driven homologous pairing and strand exchange of DNA molecules necessary for DNA recombinational repair. Catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single- stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in resp [...] | 0.491 |
nfi | xthA | b3998 | b1749 | Endonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Has a wide substrate spectrum. In addition to deoxyinosine- containing DNA, the enzyme cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures. Participates in the excision repair of hypoxanthine and xanthine (deaminated adenine and guanine) in DNA. It thereby reduces the mutagenic effects of ni [...] | Exonuclease III; Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'- 5'-exonuclease, 3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease H activities. | 0.827 |
recA | endA | b2699 | b2945 | DNA recombination and repair protein; Required for homologous recombination and the bypass of mutagenic DNA lesions by the SOS response. Catalyzes ATP-driven homologous pairing and strand exchange of DNA molecules necessary for DNA recombinational repair. Catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single- stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in resp [...] | DNA-specific endonuclease I; Has double-strand break activity; Belongs to the EndA/NucM nuclease family. | 0.645 |