node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cpdA | nudF | b3032 | b3034 | 3',5' cAMP phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specific for cAMP. | ADP-ribose pyrophosphatase; Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process. Belongs to the Nudix hydrolase family. NudF subfamily. | 0.925 |
cpdA | tolC | b3032 | b3035 | 3',5' cAMP phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specific for cAMP. | Transport channel; Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells. | 0.623 |
cpdA | yqiA | b3032 | b3031 | 3',5' cAMP phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specific for cAMP. | Acyl CoA esterase; Displays esterase activity toward palmitoyl-CoA and pNP- butyrate. | 0.981 |
cpdA | yqiB | b3032 | b3033 | 3',5' cAMP phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specific for cAMP. | DUF1249 protein YqiB; Putative enzyme. | 0.968 |
frsA | menH | b0239 | b2263 | Fermentation-respiration switch protein; Displays esterase activity toward pNP-butyrate. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro; Belongs to the AB hydrolase superfamily. MenH family. | 0.892 |
frsA | ybfF | b0239 | b0686 | Fermentation-respiration switch protein; Displays esterase activity toward pNP-butyrate. | acyl-CoA esterase; Displays esterase activity toward palmitoyl-CoA, malonyl-CoA and pNP-butyrate. | 0.792 |
frsA | yeiG | b0239 | b2154 | Fermentation-respiration switch protein; Displays esterase activity toward pNP-butyrate. | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against alpha-naphthyl acetate, lactoylglutathione, palmitoyl-CoA and several pNP-esters of short chain fatty acids. | 0.663 |
frsA | yjfP | b0239 | b4190 | Fermentation-respiration switch protein; Displays esterase activity toward pNP-butyrate. | Acyl CoA esterase; Displays esterase activity toward palmitoyl-CoA and pNP- butyrate. | 0.655 |
frsA | ypfH | b0239 | b2473 | Fermentation-respiration switch protein; Displays esterase activity toward pNP-butyrate. | palmitoyl-CoA esterase activity, uncertain physiological substrate; Displays esterase activity toward palmitoyl-CoA and pNP- butyrate. | 0.828 |
frsA | yqiA | b0239 | b3031 | Fermentation-respiration switch protein; Displays esterase activity toward pNP-butyrate. | Acyl CoA esterase; Displays esterase activity toward palmitoyl-CoA and pNP- butyrate. | 0.811 |
menH | frsA | b2263 | b0239 | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro; Belongs to the AB hydrolase superfamily. MenH family. | Fermentation-respiration switch protein; Displays esterase activity toward pNP-butyrate. | 0.892 |
menH | ybfF | b2263 | b0686 | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro; Belongs to the AB hydrolase superfamily. MenH family. | acyl-CoA esterase; Displays esterase activity toward palmitoyl-CoA, malonyl-CoA and pNP-butyrate. | 0.816 |
menH | yeiG | b2263 | b2154 | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro; Belongs to the AB hydrolase superfamily. MenH family. | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against alpha-naphthyl acetate, lactoylglutathione, palmitoyl-CoA and several pNP-esters of short chain fatty acids. | 0.811 |
menH | yjfP | b2263 | b4190 | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro; Belongs to the AB hydrolase superfamily. MenH family. | Acyl CoA esterase; Displays esterase activity toward palmitoyl-CoA and pNP- butyrate. | 0.842 |
menH | ypfH | b2263 | b2473 | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro; Belongs to the AB hydrolase superfamily. MenH family. | palmitoyl-CoA esterase activity, uncertain physiological substrate; Displays esterase activity toward palmitoyl-CoA and pNP- butyrate. | 0.903 |
menH | yqiA | b2263 | b3031 | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro; Belongs to the AB hydrolase superfamily. MenH family. | Acyl CoA esterase; Displays esterase activity toward palmitoyl-CoA and pNP- butyrate. | 0.894 |
nudF | cpdA | b3034 | b3032 | ADP-ribose pyrophosphatase; Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process. Belongs to the Nudix hydrolase family. NudF subfamily. | 3',5' cAMP phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specific for cAMP. | 0.925 |
nudF | tolC | b3034 | b3035 | ADP-ribose pyrophosphatase; Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process. Belongs to the Nudix hydrolase family. NudF subfamily. | Transport channel; Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells. | 0.635 |
nudF | yqiA | b3034 | b3031 | ADP-ribose pyrophosphatase; Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process. Belongs to the Nudix hydrolase family. NudF subfamily. | Acyl CoA esterase; Displays esterase activity toward palmitoyl-CoA and pNP- butyrate. | 0.753 |
nudF | yqiB | b3034 | b3033 | ADP-ribose pyrophosphatase; Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process. Belongs to the Nudix hydrolase family. NudF subfamily. | DUF1249 protein YqiB; Putative enzyme. | 0.980 |