STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ebgRTranscriptional repressor; Repressor for beta galactosidase alpha and beta subunits (ebgA and ebgC). Binds lactose as an inducer. (327 aa)    
Predicted Functional Partners:
ebgA
Evolved beta-D-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme; Belongs to the glycosyl hydrolase 2 family.
 
   
 0.943
idnR
Transcriptional repressor, 5-gluconate-binding; Idn operon regulator. May repress gntKU and gntT genes when growing on L-idonate.
  
   
 0.878
ygjI
Putative oxidoreductase.
 
   
 0.864
gntR
D-gluconate inducible gluconate regulon transcriptional repressor; Negative regulator for the gluconate utilization system GNT- I, the gntUKR operon.
  
  
 0.773
malI
Transcriptional repressor of Mal regulon; Repressor for the malX and malY genes. Also regulates its own expression. Binds maltose as an inducer.
  
     0.771
ebgC
Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known.
  
  
 0.746
cra
Transcriptional repressor-activator for carbon metabolism; Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism. Activates transcription of genes encoding biosynthetic and oxidative enzymes (involved in Krebs cycle, glyoxylate shunt and gluconeogenesis, such as ppsA and fbp). Represses genes involved in sugar catabolism, such as fruB, pfkA, pykF and adhE. Binds asymmetrically to the two half-sites of its operator.
  
   
 0.730
ygjK
Alpha-glucosidase; Glucoside hydrolase that cleaves the alpha-1,3-glucosidic linkage in nigerose. Has very low activity towards maltooligosaccharides, soluble starch, nigerotriose, kojibiose and trehalose.
 
     0.660
gltB
Glutamate synthase, large subunit; Catalyzes the conversion of L-glutamine and 2-oxoglutarate into two molecules of L-glutamate.
    
 
 0.655
ygjH
Putative tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation.
 
 
   0.607
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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