node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
azoR | yhaK | b1412 | b3106 | NADH-azoreductase, FMN-dependent; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. The enzyme can reduce ethyl red and methyl red, but is not able to convert sulfonated azo dyes; Belongs to the azoreductase type 1 family. | Redox-sensitive bicupin; Does not have quercetin 2,3-dioxygenase activity. Belongs to the pirin family. | 0.530 |
azoR | yhhW | b1412 | b3439 | NADH-azoreductase, FMN-dependent; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. The enzyme can reduce ethyl red and methyl red, but is not able to convert sulfonated azo dyes; Belongs to the azoreductase type 1 family. | Quercetinase activity in vitro; Has quercetin 2,3-dioxygenase activity in vitro. Its physiological role is unknown; however, may provide a mechanism that would avoid inhibition of key cellular proteins, such as DNA gyrase, by quercetin. | 0.586 |
azoR | yqjF | b1412 | b3101 | NADH-azoreductase, FMN-dependent; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. The enzyme can reduce ethyl red and methyl red, but is not able to convert sulfonated azo dyes; Belongs to the azoreductase type 1 family. | Putative quinol oxidase subunit. | 0.690 |
azoR | yqjG | b1412 | b3102 | NADH-azoreductase, FMN-dependent; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. The enzyme can reduce ethyl red and methyl red, but is not able to convert sulfonated azo dyes; Belongs to the azoreductase type 1 family. | Putative S-transferase; Catalyzes glutathione (GSH)-dependent reduction of glutathionyl-hydroquinones (GS-HQs) to the corresponding hydroquinones. Can use a variety of GS-HQs as substrates, such as GS-p-hydroquinone (GS-HQ), GS-hydroxy-p-hydroquinone (GS-HHQ), GS-methyl-p-hydroquinone (GS-MHQ), GS-menadiol, and GS-trichloro-p-hydroquinone (GS-TriCH). Also displays GSH-dependent disulfide-bond reduction activity toward HED (2- hydroxyethyl disulfide), and is able to catalyze DMA (dimethylarsinate) reduction. Exhibits no GSH transferase activity with 1-chloro-2,4- dinitrobenzene (CDNB). | 0.676 |
ybiJ | ygiD | b0802 | b3039 | DUF1471 family putative periplasmic protein. | 4,5- DOPA-extradiol-dioxygenase; In vitro, opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is unknown. | 0.740 |
ybiJ | yhaJ | b0802 | b3105 | DUF1471 family putative periplasmic protein. | LysR family putative transcriptional regulator; Positive regulator, may be partially responsible for expression of neighboring gene dlsT (yhaO) (By similarity). | 0.575 |
ybiJ | yhaK | b0802 | b3106 | DUF1471 family putative periplasmic protein. | Redox-sensitive bicupin; Does not have quercetin 2,3-dioxygenase activity. Belongs to the pirin family. | 0.879 |
ybiJ | yhhW | b0802 | b3439 | DUF1471 family putative periplasmic protein. | Quercetinase activity in vitro; Has quercetin 2,3-dioxygenase activity in vitro. Its physiological role is unknown; however, may provide a mechanism that would avoid inhibition of key cellular proteins, such as DNA gyrase, by quercetin. | 0.645 |
ybiJ | yqjF | b0802 | b3101 | DUF1471 family putative periplasmic protein. | Putative quinol oxidase subunit. | 0.808 |
ygdD | yqjF | b2807 | b3101 | UPF0382 family inner membrane protein. | Putative quinol oxidase subunit. | 0.737 |
yghQ | yjfZ | b2983 | b4204 | Putative inner membrane polysaccharide flippase. | Uncharacterized protein. | 0.544 |
yghQ | yqjF | b2983 | b3101 | Putative inner membrane polysaccharide flippase. | Putative quinol oxidase subunit. | 0.505 |
ygiD | ybiJ | b3039 | b0802 | 4,5- DOPA-extradiol-dioxygenase; In vitro, opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is unknown. | DUF1471 family putative periplasmic protein. | 0.740 |
ygiD | yhaJ | b3039 | b3105 | 4,5- DOPA-extradiol-dioxygenase; In vitro, opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is unknown. | LysR family putative transcriptional regulator; Positive regulator, may be partially responsible for expression of neighboring gene dlsT (yhaO) (By similarity). | 0.552 |
ygiD | yhaK | b3039 | b3106 | 4,5- DOPA-extradiol-dioxygenase; In vitro, opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is unknown. | Redox-sensitive bicupin; Does not have quercetin 2,3-dioxygenase activity. Belongs to the pirin family. | 0.791 |
ygiD | yhhW | b3039 | b3439 | 4,5- DOPA-extradiol-dioxygenase; In vitro, opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is unknown. | Quercetinase activity in vitro; Has quercetin 2,3-dioxygenase activity in vitro. Its physiological role is unknown; however, may provide a mechanism that would avoid inhibition of key cellular proteins, such as DNA gyrase, by quercetin. | 0.820 |
ygiD | yqjF | b3039 | b3101 | 4,5- DOPA-extradiol-dioxygenase; In vitro, opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is unknown. | Putative quinol oxidase subunit. | 0.595 |
yhaJ | ybiJ | b3105 | b0802 | LysR family putative transcriptional regulator; Positive regulator, may be partially responsible for expression of neighboring gene dlsT (yhaO) (By similarity). | DUF1471 family putative periplasmic protein. | 0.575 |
yhaJ | ygiD | b3105 | b3039 | LysR family putative transcriptional regulator; Positive regulator, may be partially responsible for expression of neighboring gene dlsT (yhaO) (By similarity). | 4,5- DOPA-extradiol-dioxygenase; In vitro, opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is unknown. | 0.552 |
yhaJ | yhaK | b3105 | b3106 | LysR family putative transcriptional regulator; Positive regulator, may be partially responsible for expression of neighboring gene dlsT (yhaO) (By similarity). | Redox-sensitive bicupin; Does not have quercetin 2,3-dioxygenase activity. Belongs to the pirin family. | 0.964 |