STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tdcRL-threonine dehydratase operon activator protein; Probable trans-acting positive activator for the tdc operon. (72 aa)    
Predicted Functional Partners:
tdcA
Tdc operon transcriptional activator; Transcriptional activator for the tdcABCDE operon. Belongs to the LysR transcriptional regulatory family.
  
  
 0.963
psuK
Pseudouridine kinase; Catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP).
      
 0.733
frlR
Putative DNA-binding transcriptional regulator; May regulate the transcription of the frlABCDR operon, involved in the utilization of fructoselysine and psicoselysine.
      
 0.733
yqeK
Uncharacterized protein.
   
    0.624
yhaB
Uncharacterized protein.
  
    0.600
tdcB
L-threonine dehydratase, catabolic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. TdcB also dehydrates serine t [...]
  
  
 0.550
yhaC
Pentapetide repeats-related protein.
  
    0.547
ydeO
UV-inducible global regulator, EvgA-, GadE-dependent; Induces the expression of gadE and mdtEF. Could also regulate the expression of other genes involved in acid resistance.
   
  
 0.536
yjjQ
Putative regulator.
   
  
 0.531
yhhZ
Putative Hcp1 family polymorphic toxin protein; putative colicin-like DNase/tRNase activity; Belongs to the hcp1 family.
   
    0.528
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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