STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yhcGDUF1016 family protein in the PD-(D/E)XK nuclease superfamily; May be a nuclease involved in DNA recombination and repair. (375 aa)    
Predicted Functional Partners:
yhcF
Putative transcriptional regulator; Protein involved in transcription and regulation of transcription, DNA-dependent; To E.coli GltF.
  
  
 0.888
yhcC
Putative Fe-S oxidoreductase, Radical SAM superfamily protein; In vitro, can cleave S-adenosyl-L-methionine into methionine and 5'-deoxyadenosine (AdoH); Belongs to the radical SAM superfamily.
      
 0.804
pinE
Serine recombinase PinE; This protein catalyzes the inversion of an 1800-bp E.coli DNA fragment, the P region, which can exist in either orientation. The function of the inversion is not yet clear.
  
  
 0.670
rtcB
RNA-splicing ligase; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases.
   
  
 0.654
ychE
UPF0056 family inner membrane protein; Putative channel protein.
      
 0.645
rbsB
D-ribose ABC transporter periplasmic binding protein; Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose. Also serves as the primary chemoreceptor for chemotaxis; Belongs to the bacterial solute-binding protein 2 family.
      
 0.601
yigE
DUF2233 family protein.
      
 0.600
lspA
Prolipoprotein signal peptidase (signal peptidase II); This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
      
 0.559
yraN
UPF0102 family protein; Belongs to the UPF0102 family.
      
 0.554
intS
CPS-53 (KpLE1) prophage; Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.
  
  
 0.544
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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