node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ampE | lpoA | b0111 | b3147 | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | OM lipoprotein stimulator of MrcA transpeptidase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro. | 0.640 |
ampE | yacL | b0111 | b0119 | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | UPF0231 family protein. | 0.544 |
ampE | ycdY | b0111 | b1035 | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | Redox enzyme maturation protein (REMP) chaperone for YcdX; Acts as a chaperone that increases YcdX activity, maybe by facilitating the correct insertion of the zinc ions into the catalytic site of YcdX. Involved in the swarming motility process. | 0.720 |
ampE | yeeA | b0111 | b2008 | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | Putative transporter, FUSC family inner membrane protein. | 0.752 |
ampE | yhfK | b0111 | b3358 | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | Putative transporter, FUSC superfamily inner membrane protein; Protein involved in metabolic process. | 0.755 |
ampE | yhjJ | b0111 | b3527 | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | Putative periplasmic M16 family chaperone; Belongs to the peptidase M16 family. | 0.638 |
crp | yacL | b3357 | b0119 | cAMP-activated global transcription factor, mediator of catabolite repression; A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome. There are 3 classes of CRP promoters; class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)-binding site, whereas in class II promoters the single CRP- and RNAP-binding site [...] | UPF0231 family protein. | 0.845 |
crp | yhfA | b3357 | b3356 | cAMP-activated global transcription factor, mediator of catabolite repression; A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome. There are 3 classes of CRP promoters; class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)-binding site, whereas in class II promoters the single CRP- and RNAP-binding site [...] | OsmC family protein. | 0.528 |
crp | yhfK | b3357 | b3358 | cAMP-activated global transcription factor, mediator of catabolite repression; A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome. There are 3 classes of CRP promoters; class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)-binding site, whereas in class II promoters the single CRP- and RNAP-binding site [...] | Putative transporter, FUSC superfamily inner membrane protein; Protein involved in metabolic process. | 0.773 |
lpoA | ampE | b3147 | b0111 | OM lipoprotein stimulator of MrcA transpeptidase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro. | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | 0.640 |
lpoA | yacL | b3147 | b0119 | OM lipoprotein stimulator of MrcA transpeptidase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro. | UPF0231 family protein. | 0.453 |
lpoA | ycdY | b3147 | b1035 | OM lipoprotein stimulator of MrcA transpeptidase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro. | Redox enzyme maturation protein (REMP) chaperone for YcdX; Acts as a chaperone that increases YcdX activity, maybe by facilitating the correct insertion of the zinc ions into the catalytic site of YcdX. Involved in the swarming motility process. | 0.762 |
lpoA | yeeA | b3147 | b2008 | OM lipoprotein stimulator of MrcA transpeptidase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro. | Putative transporter, FUSC family inner membrane protein. | 0.507 |
lpoA | yhfK | b3147 | b3358 | OM lipoprotein stimulator of MrcA transpeptidase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro. | Putative transporter, FUSC superfamily inner membrane protein; Protein involved in metabolic process. | 0.653 |
lpoA | yhjJ | b3147 | b3527 | OM lipoprotein stimulator of MrcA transpeptidase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro. | Putative periplasmic M16 family chaperone; Belongs to the peptidase M16 family. | 0.723 |
yacL | ampE | b0119 | b0111 | UPF0231 family protein. | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | 0.544 |
yacL | crp | b0119 | b3357 | UPF0231 family protein. | cAMP-activated global transcription factor, mediator of catabolite repression; A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome. There are 3 classes of CRP promoters; class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)-binding site, whereas in class II promoters the single CRP- and RNAP-binding site [...] | 0.845 |
yacL | lpoA | b0119 | b3147 | UPF0231 family protein. | OM lipoprotein stimulator of MrcA transpeptidase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro. | 0.453 |
yacL | ycdY | b0119 | b1035 | UPF0231 family protein. | Redox enzyme maturation protein (REMP) chaperone for YcdX; Acts as a chaperone that increases YcdX activity, maybe by facilitating the correct insertion of the zinc ions into the catalytic site of YcdX. Involved in the swarming motility process. | 0.700 |
yacL | ydhK | b0119 | b1645 | UPF0231 family protein. | Putative efflux protein (PET) component of YdhJK efflux pump. | 0.413 |