node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
frwA | fryA | b3947 | b2383 | Putative PTS enzyme: Hpr, enzyme I and II components; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport. | Putative PTS enzyme: Hpr, enzyme I and IIA components; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport. | 0.921 |
frwA | lacI | b3947 | b0345 | Putative PTS enzyme: Hpr, enzyme I and II components; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport. | Lactose-inducible lac operon transcriptional repressor; Repressor of the lactose operon. Binds allolactose as an inducer. | 0.514 |
frwA | xylR | b3947 | b3569 | Putative PTS enzyme: Hpr, enzyme I and II components; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport. | Xylose divergent operon transcriptional activator; Regulatory protein for the xylBAFGHR operon. | 0.717 |
fryA | frwA | b2383 | b3947 | Putative PTS enzyme: Hpr, enzyme I and IIA components; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport. | Putative PTS enzyme: Hpr, enzyme I and II components; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport. | 0.921 |
fryA | lacI | b2383 | b0345 | Putative PTS enzyme: Hpr, enzyme I and IIA components; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport. | Lactose-inducible lac operon transcriptional repressor; Repressor of the lactose operon. Binds allolactose as an inducer. | 0.514 |
fryA | xylR | b2383 | b3569 | Putative PTS enzyme: Hpr, enzyme I and IIA components; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport. | Xylose divergent operon transcriptional activator; Regulatory protein for the xylBAFGHR operon. | 0.717 |
glnG | xylR | b3868 | b3569 | DNA-binding transcriptional regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. Activates transcription of many genes and operons whose products minimize the slowing of growth under nitrogen-limiting conditions, including genes coding for glutamine synthetase (glnA), transporters, amino acid permeases and catabolic enzymes. | Xylose divergent operon transcriptional activator; Regulatory protein for the xylBAFGHR operon. | 0.781 |
lacI | frwA | b0345 | b3947 | Lactose-inducible lac operon transcriptional repressor; Repressor of the lactose operon. Binds allolactose as an inducer. | Putative PTS enzyme: Hpr, enzyme I and II components; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport. | 0.514 |
lacI | fryA | b0345 | b2383 | Lactose-inducible lac operon transcriptional repressor; Repressor of the lactose operon. Binds allolactose as an inducer. | Putative PTS enzyme: Hpr, enzyme I and IIA components; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport. | 0.514 |
lacI | xylR | b0345 | b3569 | Lactose-inducible lac operon transcriptional repressor; Repressor of the lactose operon. Binds allolactose as an inducer. | Xylose divergent operon transcriptional activator; Regulatory protein for the xylBAFGHR operon. | 0.730 |
xylA | xylB | b3565 | b3564 | D-xylose isomerase; Protein involved in carbohydrate catabolic process and glucose metabolic process; Belongs to the xylose isomerase family. | Xylulokinase; Catalyzes the phosphorylation of D-xylulose to D-xylulose 5- phosphate. Also catalyzes the phosphorylation of 1- deoxy-D-xylulose to 1-deoxy-D-xylulose 5-phosphate, with lower efficiency. Can also use D-ribulose, xylitol and D- arabitol, but D-xylulose is preferred over the other substrates. Has a weak substrate-independent Mg-ATP-hydrolyzing activity ; Belongs to the FGGY kinase family. | 0.999 |
xylA | xylE | b3565 | b4031 | D-xylose isomerase; Protein involved in carbohydrate catabolic process and glucose metabolic process; Belongs to the xylose isomerase family. | D-xylose transporter; Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Glucose is not transported, but can compete for xylose binding sites and can inhibit xylose transport (in vitro). Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.930 |
xylA | xylF | b3565 | b3566 | D-xylose isomerase; Protein involved in carbohydrate catabolic process and glucose metabolic process; Belongs to the xylose isomerase family. | D-xylose transporter subunit; Involved in the high-affinity D-xylose membrane transport system. Binds with high affinity to xylose. | 0.978 |
xylA | xylG | b3565 | b3567 | D-xylose isomerase; Protein involved in carbohydrate catabolic process and glucose metabolic process; Belongs to the xylose isomerase family. | D-xylose ABC transporter dual domain ATPase; Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system (Probable). The XylFGH system can also transport ribose in absence of xylose; Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family. | 0.875 |
xylA | xylH | b3565 | b3568 | D-xylose isomerase; Protein involved in carbohydrate catabolic process and glucose metabolic process; Belongs to the xylose isomerase family. | D-xylose ABC transporter permease; Part of the binding-protein-dependent transport system for D- xylose. Probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. | 0.791 |
xylA | xylR | b3565 | b3569 | D-xylose isomerase; Protein involved in carbohydrate catabolic process and glucose metabolic process; Belongs to the xylose isomerase family. | Xylose divergent operon transcriptional activator; Regulatory protein for the xylBAFGHR operon. | 0.965 |
xylB | xylA | b3564 | b3565 | Xylulokinase; Catalyzes the phosphorylation of D-xylulose to D-xylulose 5- phosphate. Also catalyzes the phosphorylation of 1- deoxy-D-xylulose to 1-deoxy-D-xylulose 5-phosphate, with lower efficiency. Can also use D-ribulose, xylitol and D- arabitol, but D-xylulose is preferred over the other substrates. Has a weak substrate-independent Mg-ATP-hydrolyzing activity ; Belongs to the FGGY kinase family. | D-xylose isomerase; Protein involved in carbohydrate catabolic process and glucose metabolic process; Belongs to the xylose isomerase family. | 0.999 |
xylB | xylE | b3564 | b4031 | Xylulokinase; Catalyzes the phosphorylation of D-xylulose to D-xylulose 5- phosphate. Also catalyzes the phosphorylation of 1- deoxy-D-xylulose to 1-deoxy-D-xylulose 5-phosphate, with lower efficiency. Can also use D-ribulose, xylitol and D- arabitol, but D-xylulose is preferred over the other substrates. Has a weak substrate-independent Mg-ATP-hydrolyzing activity ; Belongs to the FGGY kinase family. | D-xylose transporter; Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Glucose is not transported, but can compete for xylose binding sites and can inhibit xylose transport (in vitro). Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.898 |
xylB | xylF | b3564 | b3566 | Xylulokinase; Catalyzes the phosphorylation of D-xylulose to D-xylulose 5- phosphate. Also catalyzes the phosphorylation of 1- deoxy-D-xylulose to 1-deoxy-D-xylulose 5-phosphate, with lower efficiency. Can also use D-ribulose, xylitol and D- arabitol, but D-xylulose is preferred over the other substrates. Has a weak substrate-independent Mg-ATP-hydrolyzing activity ; Belongs to the FGGY kinase family. | D-xylose transporter subunit; Involved in the high-affinity D-xylose membrane transport system. Binds with high affinity to xylose. | 0.924 |
xylB | xylG | b3564 | b3567 | Xylulokinase; Catalyzes the phosphorylation of D-xylulose to D-xylulose 5- phosphate. Also catalyzes the phosphorylation of 1- deoxy-D-xylulose to 1-deoxy-D-xylulose 5-phosphate, with lower efficiency. Can also use D-ribulose, xylitol and D- arabitol, but D-xylulose is preferred over the other substrates. Has a weak substrate-independent Mg-ATP-hydrolyzing activity ; Belongs to the FGGY kinase family. | D-xylose ABC transporter dual domain ATPase; Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system (Probable). The XylFGH system can also transport ribose in absence of xylose; Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family. | 0.851 |